ERD1/YDR414C Summary Help

Standard Name ERD1 1, 2
Systematic Name YDR414C
Alias LDB2
Feature Type ORF, Verified
Description Predicted membrane protein required for lumenal ER protein retention; mutants secrete the endogenous ER protein, BiP (Kar2p) (1, 2)
Name Description Endoplasmic reticulum Retention Defective 2
Chromosomal Location
ChrIV:1296686 to 1295598 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ERD1 GO evidence and references
  View Computational GO annotations for ERD1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
400 total interaction(s) for 254 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • PCA: 42
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 252
  • Phenotypic Enhancement: 6
  • Phenotypic Suppression: 68
  • Positive Genetic: 16
  • Synthetic Growth Defect: 9
  • Synthetic Lethality: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 362
Molecular Weight (Da) 43,230
Isoelectric Point (pI) 9.6
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1296686 to 1295598 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1089 1296686..1295598 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002822
References cited on this page View Complete Literature Guide for ERD1
1) Hardwick KG, et al.  (1990) ERD1, a yeast gene required for the retention of luminal endoplasmic reticulum proteins, affects glycoprotein processing in the Golgi apparatus. EMBO J 9(3):623-30
2) Pelham HR, et al.  (1988) Sorting of soluble ER proteins in yeast. EMBO J 7(6):1757-62