SIZ1/YDR409W Summary Help

Standard Name SIZ1 1
Systematic Name YDR409W
Alias ULL1 2
Feature Type ORF, Verified
Description SUMO/Smt3 ligase; promotes attachment of small ubiquitin-related modifier sumo (Smt3p) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring; SIZ1 has a paralog, NFI1, that arose from the whole genome duplication (3, 4, 5)
Name Description SAP and mIZ-finger domain 1
Chromosomal Location
ChrIV:1289406 to 1292120 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SIZ1 GO evidence and references
  View Computational GO annotations for SIZ1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 72 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
239 total interaction(s) for 140 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 84
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 12
  • Biochemical Activity: 13
  • Co-crystal Structure: 1
  • Reconstituted Complex: 7
  • Two-hybrid: 9

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 9
  • Phenotypic Enhancement: 17
  • Phenotypic Suppression: 20
  • Positive Genetic: 3
  • Synthetic Growth Defect: 33
  • Synthetic Lethality: 7
  • Synthetic Rescue: 20

Resources
Expression Summary
histogram
Resources
Length (a.a.) 904
Molecular Weight (Da) 100,795
Isoelectric Point (pI) 6.91
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1289406 to 1292120 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2715 1289406..1292120 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002817
References cited on this page View Complete Literature Guide for SIZ1
1) Strunnikov AV, et al.  (2001) Saccharomyces cerevisiae SMT4 encodes an evolutionarily conserved protease with a role in chromosome condensation regulation. Genetics 158(1):95-107
2) Takahashi Y, et al.  (2001) Yeast Ull1/Siz1 is a novel SUMO1/Smt3 ligase for septin components and functions as an adaptor between conjugating enzyme and substrates. J Biol Chem 276(52):48973-7
3) Takahashi Y, et al.  (2001) A novel factor required for the SUMO1/Smt3 conjugation of yeast septins. Gene 275(2):223-31
4) Hochstrasser M  (2001) SP-RING for SUMO: new functions bloom for a ubiquitin-like protein. Cell 107(1):5-8
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61