SIZ1/YDR409W Summary Help

SIZ1 BASIC INFORMATION

Standard Name SIZ1 1
Systematic Name YDR409W
Alias ULL1 2
Feature Type ORF, Verified
Description SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring (3, 4)
Name Description SAP and mIZ-finger domain 1
GO Annotations All SIZ1 GO evidence and references
    View Computational GO annotations for SIZ1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All SIZ1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions SIZ1 All interactions details and references
73 total interaction(s) for 44 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 4
  • Biochemical Activity: 3
  • Reconstituted Complex: 5
  • Two-hybrid: 7
Genetic Interactions
  • Phenotypic Enhancement: 12
  • Phenotypic Suppression: 11
  • Synthetic Growth Defect: 11
  • Synthetic Lethality: 2
  • Synthetic Rescue: 14
Sequence Information
ChrIV:1289399 to 1292113 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2715 1289399..1292113 2008-06-05 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002817

SIZ1 RESOURCES

Click on map for expanded view
SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SIZ1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SIZ1]

1) Strunnikov AV, et al.  (2001) Saccharomyces cerevisiae SMT4 encodes an evolutionarily conserved protease with a role in chromosome condensation regulation. Genetics 158(1):95-107
2) Takahashi Y, et al.  (2001) Yeast Ull1/Siz1 is a novel SUMO1/Smt3 ligase for septin components and functions as an adaptor between conjugating enzyme and substrates. J Biol Chem 276(52):48973-7
3) Takahashi Y, et al.  (2001) A novel factor required for the SUMO1/Smt3 conjugation of yeast septins. Gene 275(2):223-31
4) Hochstrasser M  (2001) SP-RING for SUMO: new functions bloom for a ubiquitin-like protein. Cell 107(1):5-8