Standard Name	SAC7 1
Systematic Name	YDR389W
Feature Type	ORF, Verified
Description	GTPase activating protein (GAP) for Rho1p; involved in signaling to actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate; SAC7 has a paralog, BAG7, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description	Suppressor of ACtin 6

Chromosomal Location	ChrIV:1252537 to 1254501 | ORF Map | GBrowse
	Genetic position: 220 cM

	View Computational GO annotations for SAC7
Molecular Function
Manually curated	Rho GTPase activator activity (TAS)
Biological Process
Manually curated	actin filament reorganization involved in cell cycle (IMP) small GTPase mediated signal transduction (TAS)
Cellular Component
Manually curated	intracellular (TAS)

Classical genetics
null	resistance to sodium dodecyl sulfate: decreased
Large-scale survey
null	auxotrophy competitive fitness: decreased dessication resistance: decreased ionic stress resistance: decreased resistance to wortmannin: increased resistance to sirolimus: decreased resistance to doxorubicin: decreased resistance to tunicamycin: decreased resistance to neothyonidioside: decreased resistance to fenpropimorph: decreased resistance to bleomycin: increased resistance to L-1,4-dithiothreitol: decreased resistance to calcium dichloride: decreased resistance to hygromycin B: decreased resistance to benzo[a]pyrene: decreased sporulation: decreased sporulation efficiency: decreased toxin resistance: decreased vacuolar morphology: abnormal viable
overexpression	inviable vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	179 total interaction(s) for 139 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 1 Reconstituted Complex: 1 Two-hybrid: 4
Genetic Interactions	Dosage Growth Defect: 3 Dosage Lethality: 4 Dosage Rescue: 8 Negative Genetic: 52 Phenotypic Enhancement: 14 Phenotypic Suppression: 9 Positive Genetic: 20 Synthetic Growth Defect: 31 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 8 Synthetic Rescue: 18
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1252537 to 1254501 | ORF Map | GBrowse
	Genetic position: 220 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1965 1252537..1254501 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002797