SAC7/YDR389W Summary Help

SAC7 BASIC INFORMATION

Standard Name SAC7 1
Systematic Name YDR389W
Feature Type ORF, Verified
Description GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate (1, 2, 3, 4)
Name Description Suppressor of ACtin 5
GO Annotations All SAC7 GO evidence and references
    View Computational GO annotations for SAC7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All SAC7 Phenotype details and references
Classical genetics
null
Large-scale survey
null
overexpression
Interactions SAC7 All interactions details and references
61 total interaction(s) for 47 unique genes/features.
Physical Interactions
  • Affinity Capture-Western: 1
  • Biochemical Activity: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 4
Genetic Interactions
  • Dosage Lethality: 3
  • Dosage Rescue: 5
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 22
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 7
  • Synthetic Rescue: 14
Sequence Information
ChrIV:1252530 to 1254494 | ORF Map | GBrowse
Gbrowse
Genetic position: 220 cM
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1965 1252530..1254494 2008-06-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002797

SAC7 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Localization Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for SAC7

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SAC7]

1) Dunn TM and Shortle D  (1990) Null alleles of SAC7 suppress temperature-sensitive actin mutations in Saccharomyces cerevisiae. Mol Cell Biol 10(5):2308-14
2) Schmidt A, et al.  (1997) The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Cell 88(4):531-42
3) Schmidt A, et al.  (2002) The RHO1-GAPs SAC7, BEM2 and BAG7 control distinct RHO1 functions in Saccharomyces cerevisiae. Mol Microbiol 45(5):1433-41
4) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
5) Novick P, et al.  (1989) Suppressors of yeast actin mutations. Genetics 121(4):659-74