MUS81/YDR386W Summary Help

MUS81 BASIC INFORMATION

Standard Name MUS81 1
Systematic Name YDR386W
Alias SLX3
Feature Type ORF, Verified
Description Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein (1, 2, 3, 4, 5)
Name Description MMS and UV Sensitive 1
GO Annotations All MUS81 GO evidence and references
    View Computational GO annotations for MUS81
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All MUS81 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions MUS81 All interactions details and references
173 total interaction(s) for 104 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 32
  • Affinity Capture-Western: 3
  • Co-purification: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 7
Genetic Interactions
  • Phenotypic Enhancement: 37
  • Phenotypic Suppression: 3
  • Synthetic Growth Defect: 49
  • Synthetic Lethality: 36
  • Synthetic Rescue: 2
Sequence Information
ChrIV:1246077 to 1247975 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1899 1246077..1247975 2008-06-05 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002794

MUS81 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for MUS81

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MUS81]

1) Interthal H and Heyer WD  (2000) MUS81 encodes a novel helix-hairpin-helix protein involved in the response to UV- and methylation-induced DNA damage in Saccharomyces cerevisiae. Mol Gen Genet 263(5):812-27
2) Bastin-Shanower SA, et al.  (2003) The mechanism of Mus81-Mms4 cleavage site selection distinguishes it from the homologous endonuclease Rad1-Rad10. Mol Cell Biol 23(10):3487-96
3) Fu Y and Xiao W  (2003) Functional domains required for the Saccharomyces cerevisiae Mus81-Mms4 endonuclease complex formation and nuclear localization. DNA Repair (Amst) 2(12):1435-47
4) Oh SD, et al.  (2008) RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination. Mol Cell 31(3):324-36
5) Jessop L and Lichten M  (2008) Mus81/Mms4 endonuclease and Sgs1 helicase collaborate to ensure proper recombination intermediate metabolism during meiosis. Mol Cell 31(3):313-23