Standard Name	YRA1 1
Systematic Name	YDR381W
Alias	SHE11 2
Feature Type	ORF, Verified
Description	Nuclear polyadenylated RNA-binding protein; required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; interacts with DBP2; inhibits the helicase activity of Dbp2; functionally redundant with Yra2p, another REF family member (1, 3, 4, 5, 6)
Name Description	Yeast RNA Annealing protein 1

Chromosomal Location	ChrIV:1236558 to 1238004 | ORF Map | GBrowse

	View Computational GO annotations for YRA1
Molecular Function
Manually curated	RNA binding (IDA)
Biological Process
Manually curated	mRNA export from nucleus (IGI) transcription-coupled nucleotide-excision repair (IMP)
Cellular Component
Manually curated	transcription export complex (IPI)

Classical genetics
overexpression	budding index: decreased vegetative growth: arrested
reduction of function	heat sensitivity: increased resistance to benomyl: decreased resistance to hydroxyurea: decreased vegetative growth: decreased
Large-scale survey
null	inviable
overexpression	cell cycle progression: abnormal
reduction of function	competitive fitness: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	405 total interaction(s) for 276 unique genes/features.
Physical Interactions	Affinity Capture-MS: 300 Affinity Capture-RNA: 4 Affinity Capture-Western: 33 Far Western: 1 Reconstituted Complex: 10 Two-hybrid: 5
Genetic Interactions	Dosage Growth Defect: 4 Dosage Rescue: 6 Negative Genetic: 8 Phenotypic Enhancement: 1 Synthetic Growth Defect: 4 Synthetic Lethality: 23 Synthetic Rescue: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1236558 to 1238004 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1999-07-17
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..285 1236558..1236842 2011-02-03 1999-07-17 Intron 286..1051 1236843..1237608 2011-02-03 1999-07-17 CDS 1052..1447 1237609..1238004 2011-02-03 1999-07-17
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (286 - 1051)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002789