YRA1/YDR381W Summary Help

YRA1 BASIC INFORMATION

Standard Name YRA1 1
Systematic Name YDR381W
Alias SHE11 2
Feature Type ORF, Verified
Description RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member (1, 3, 4, 5)
Name Description Yeast RNA Annealing protein 1
GO Annotations All YRA1 GO evidence and references
    View Computational GO annotations for YRA1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All YRA1 Phenotype details and references
Classical genetics
overexpression
Large-scale survey
null
Interactions YRA1 All interactions details and references
351 total interaction(s) for 246 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 273
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 28
  • Reconstituted Complex: 5
  • Two-hybrid: 4
Genetic Interactions
  • Dosage Growth Defect: 4
  • Dosage Rescue: 4
  • Phenotypic Enhancement: 7
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 18
  • Synthetic Rescue: 3
Sequence Information
ChrIV:1236551 to 1237997 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2008-06-05 | Sequence: 1999-07-17
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..285 1236551..1236835 2008-06-05 1999-07-17
Intron 286..1051 1236836..1237601 2008-06-05 1999-07-17
CDS 1052..1447 1237602..1237997 2008-06-05 1999-07-17
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002789

YRA1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for YRA1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for YRA1]

1) Portman DS, et al.  (1997) YRA1, an essential Saccharomyces cerevisiae gene, encodes a novel nuclear protein with RNA annealing activity. RNA 3(5):527-37
2) Espinet C, et al.  (1995) An efficient method to isolate yeast genes causing overexpression-mediated growth arrest. Yeast 11(1):25-32
3) Zenklusen D, et al.  (2001) The yeast hnRNP-Like proteins Yra1p and Yra2p participate in mRNA export through interaction with Mex67p. Mol Cell Biol 21(13):4219-32
4) Strasser K and Hurt E  (2000) Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export. EMBO J 19(3):410-20
5) Johnson SA, et al.  (2009) Cotranscriptional recruitment of the mRNA export factor Yra1 by direct interaction with the 3' end processing factor Pcf11. Mol Cell 33(2):215-26