YRA1/YDR381W Summary Help

Standard Name YRA1 1
Systematic Name YDR381W
Alias SHE11 2
Feature Type ORF, Verified
Description Nuclear polyadenylated RNA-binding protein; required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; interacts with DBP2; inhibits the helicase activity of Dbp2; functionally redundant with Yra2p, another REF family member (1, 3, 4, 5, 6)
Name Description Yeast RNA Annealing protein 1
Chromosomal Location
ChrIV:1236558 to 1238004 | ORF Map | GBrowse
Gene Ontology Annotations All YRA1 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 8 genes
Classical genetics
reduction of function
Large-scale survey
reduction of function
414 total interaction(s) for 277 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 303
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 34
  • Co-localization: 1
  • Far Western: 1
  • Reconstituted Complex: 11
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Growth Defect: 4
  • Dosage Rescue: 6
  • Negative Genetic: 8
  • Phenotypic Enhancement: 1
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 24
  • Synthetic Rescue: 6

Expression Summary
Length (a.a.) 226
Molecular Weight (Da) 24,955
Isoelectric Point (pI) 11.9
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIV:1236558 to 1238004 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1999-07-17
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..285 1236558..1236842 2011-02-03 1999-07-17
Intron 286..1051 1236843..1237608 2011-02-03 1999-07-17
CDS 1052..1447 1237609..1238004 2011-02-03 1999-07-17
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002789
References cited on this page View Complete Literature Guide for YRA1
1) Portman DS, et al.  (1997) YRA1, an essential Saccharomyces cerevisiae gene, encodes a novel nuclear protein with RNA annealing activity. RNA 3(5):527-37
2) Espinet C, et al.  (1995) An efficient method to isolate yeast genes causing overexpression-mediated growth arrest. Yeast 11(1):25-32
3) Zenklusen D, et al.  (2001) The yeast hnRNP-Like proteins Yra1p and Yra2p participate in mRNA export through interaction with Mex67p. Mol Cell Biol 21(13):4219-32
4) Strasser K and Hurt E  (2000) Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export. EMBO J 19(3):410-20
5) Johnson SA, et al.  (2009) Cotranscriptional recruitment of the mRNA export factor Yra1 by direct interaction with the 3' end processing factor Pcf11. Mol Cell 33(2):215-26
6) Ma WK, et al.  (2013) The DEAD-box Protein Dbp2 Functions with the RNA-Binding Protein Yra1 to Promote mRNP Assembly. J Mol Biol 425(20):3824-3838