RGA2/YDR379W Summary

RGA2 BASIC INFORMATION

Standard Name	RGA2 1
Systematic Name	YDR379W
Feature Type	ORF, Verified
Description	GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p (1, 2)
Name Description	Rho GTPase Activating Protein 1

GO Annotations	All RGA2 GO evidence and references
	View Computational GO annotations for RGA2
Molecular Function
Manually curated	Rho GTPase activator activity (IDA, IGI, IPI, ISA)
Biological Process
Manually curated	actin filament organization (ISS) budding cell apical bud growth (ISS) budding cell isotropic bud growth (ISS) establishment of cell polarity (TAS) invasive growth in response to glucose limitation (ISS) pheromone-dependent signal transduction involved in conjugation with cellular fusion (TAS) pseudohyphal growth (ISS) small GTPase mediated signal transduction (TAS)
Cellular Component
Manually curated	cellular bud neck split septin rings (IDA)

Mutant Phenotype	All RGA2 Phenotype details and references
Classical genetics
null	Kss1p modification: increased
overexpression	cellular morphology: abnormal utilization of carbon source: absent
Large-scale survey
null	budding index: decreased viable
overexpression	vegetative growth: decreased

Interactions	RGA2 All interactions details and references
	33 total interaction(s) for 27 unique genes/features.
Physical Interactions	Affinity Capture-MS: 10 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Biochemical Activity: 6 PCA: 1 Two-hybrid: 5
Genetic Interactions	Dosage Lethality: 3 Dosage Rescue: 2 Phenotypic Enhancement: 1 Synthetic Growth Defect: 2

Sequence Information

ChrIV:1230160 to 1233189 | |

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..3030	1230160..1233189	2008-06-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002787

RGA2 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for RGA2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RGA2]

1)	Smith GR, et al. (2002) GTPase-activating proteins for Cdc42. Eukaryot Cell 1(3):469-80
2)	Sopko R, et al. (2007) Activation of the Cdc42p GTPase by cyclin-dependent protein kinases in budding yeast. EMBO J 26(21):4487-500

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