Standard Name	BCS1
Systematic Name	YDR375C
Feature Type	ORF, Verified
Description	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases (1, 2, 3)
Name Description	ubiquinol-cytochrome c reductase (bc1) Synthesis

Chromosomal Location	ChrIV:1226536 to 1225166 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for BCS1
Molecular Function
Manually curated	ATPase activity (ISS) protein transmembrane transporter activity (IMP)
Biological Process
Manually curated	chaperone-mediated protein complex assembly (IMP, IPI) mitochondrial respiratory chain complex III assembly (IMP) protein insertion into mitochondrial membrane from inner side (IMP, IPI)
Cellular Component
Manually curated	mitochondrial inner membrane (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
conditional	Rip1p accumulation: decreased respiratory growth: absent
null	tellurium atom accumulation: decreased chronological lifespan: decreased
reduction of function	Rip1p accumulation: decreased respiratory growth: decreased rate respiratory growth: absent
Large-scale survey
null	cell cycle progression in G1 phase: increased duration glycogen accumulation: decreased competitive fitness: decreased dessication resistance: decreased resistance to neomycin: decreased resistance to cycloheximide: decreased resistance to ethanol: decreased resistance to elesclomol-Cu: decreased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased respiratory growth: absent respiratory growth: decreased rate utilization of carbon source: decreased vegetative growth: decreased rate viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	111 total interaction(s) for 76 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-Western: 5 Reconstituted Complex: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 95 Positive Genetic: 4 Synthetic Growth Defect: 2 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1226536 to 1225166 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1371 1226536..1225166 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002783