EAF1/YDR359C Summary Help

EAF1 BASIC INFORMATION

Standard Name EAF1 1
Systematic Name YDR359C
Alias VID21 2
Feature Type ORF, Verified
Description Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1 (3, 4, 5)
Name Description Esa1p-Associated Factor 1
GO Annotations All EAF1 GO evidence and references
    View Computational GO annotations for EAF1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All EAF1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions EAF1 All interactions details and references
497 total interaction(s) for 302 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 58
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 26
  • Co-purification: 1
  • Two-hybrid: 1
Genetic Interactions
  • Phenotypic Enhancement: 72
  • Phenotypic Suppression: 11
  • Synthetic Growth Defect: 228
  • Synthetic Lethality: 96
  • Synthetic Rescue: 3
Sequence Information
ChrIV:1194878 to 1191930 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2008-06-05 | Sequence: 2004-02-06
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2949 1194878..1191930 2008-06-05 2004-02-06
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002767

EAF1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for EAF1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for EAF1]

1) Nourani A, et al.  (2001) Role of an ING1 growth regulator in transcriptional activation and targeted histone acetylation by the NuA4 complex. Mol Cell Biol 21(22):7629-40
2) Bonangelino CJ, et al.  (2002) Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Mol Biol Cell 13(7):2486-501
3) Nourani A, et al.  (2003) Opposite role of yeast ING family members in p53-dependent transcriptional activation. J Biol Chem 278(21):19171-5
4) Jordan PW, et al.  (2007) Novel roles for selected genes in meiotic DNA processing. PLoS Genet 3(12):e222
5) Auger A, et al.  (2008) Eaf1 is the platform for NuA4 molecular assembly that evolutionarily links chromatin acetylation to ATP-dependent exchange of histone H2A variants. Mol Cell Biol 28(7):2257-70