SPC110/YDR356W Summary Help

SPC110 BASIC INFORMATION

Standard Name SPC110 1
Systematic Name YDR356W
Alias XCM1 2 , NUF1 3
Feature Type ORF, Verified
Description Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner (2, 3, 4, 5, 6)
Name Description Spindle Pole Component 1
GO Annotations All SPC110 GO evidence and references
    View Computational GO annotations for SPC110
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All SPC110 Phenotype details and references
Classical genetics
conditional
Large-scale survey
null
Interactions SPC110 All interactions details and references
128 total interaction(s) for 57 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 15
  • Biochemical Activity: 4
  • Co-purification: 40
  • FRET: 10
  • Reconstituted Complex: 8
  • Two-hybrid: 13
Genetic Interactions
  • Dosage Lethality: 3
  • Dosage Rescue: 15
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 2
  • Synthetic Lethality: 10
  • Synthetic Rescue: 2
Sequence Information
ChrIV:1186101 to 1188935 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2835 1186101..1188935 2008-06-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002764

SPC110 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Localization Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for SPC110

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SPC110]

1) Kilmartin JV, et al.  (1993) A spacer protein in the Saccharomyces cerevisiae spindle poly body whose transcript is cell cycle-regulated. J Cell Biol 123(5):1175-84
2) Geiser JR, et al.  (1993) The essential mitotic target of calmodulin is the 110-kilodalton component of the spindle pole body in Saccharomyces cerevisiae. Mol Cell Biol 13(12):7913-24
3) Mirzayan C, et al.  (1992) The NUF1 gene encodes an essential coiled-coil related protein that is a potential component of the yeast nucleoskeleton. J Cell Biol 116(6):1319-32
4) Flory MR, et al.  (2000) Identification of a human centrosomal calmodulin-binding protein that shares homology with pericentrin. Proc Natl Acad Sci U S A 97(11):5919-23
5) Knop M and Schiebel E  (1997) Spc98p and Spc97p of the yeast gamma-tubulin complex mediate binding to the spindle pole body via their interaction with Spc110p. EMBO J 16(23):6985-95
6) Friedman DB, et al.  (2001) Yeast Mps1p phosphorylates the spindle pole component Spc110p in the N-terminal domain. J Biol Chem 276(21):17958-67