PAL1/YDR348C Summary Help

Standard Name PAL1 1
Systematic Name YDR348C
Feature Type ORF, Verified
Description Protein of unknown function thought to be involved in endocytosis; physically interacts with Ede1p and is found at endocytic sites at cell periphery during early stages of endocytosis; green fluorescent protein (GFP)-fusion protein localizes to bud neck; potential Cdc28p substrate; similar to S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress; PAL1 has a paralog, YHR097C, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Pears And Lemons 5
Chromosomal Location
ChrIV:1171825 to 1170326 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PAL1 GO evidence and references
  View Computational GO annotations for PAL1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
45 total interaction(s) for 37 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 15
  • Biochemical Activity: 1
  • PCA: 1
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 25
  • Synthetic Growth Defect: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 499
Molecular Weight (Da) 54,995
Isoelectric Point (pI) 10.32
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1171825 to 1170326 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1500 1171825..1170326 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002756
References cited on this page View Complete Literature Guide for PAL1
1) Carroll SY, et al.  (2012) Analysis of yeast endocytic site formation and maturation through a regulatory transition point. Mol Biol Cell 23(4):657-68
2) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
5) Carroll SY, et al.  (2011) Personal Communication to SGD ()