MSN5/YDR335W Summary Help

MSN5 BASIC INFORMATION

Standard Name MSN5
Systematic Name YDR335W
Alias KAP142 , STE21 1
Feature Type ORF, Verified
Description Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm (2, 3, 4, 5, 6, 7)
Name Description Multicopy suppressor of SNF1 mutation
GO Annotations All MSN5 GO evidence and references
    View Computational GO annotations for MSN5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All MSN5 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Interactions MSN5 All interactions details and references
176 total interaction(s) for 135 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 19
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 15
  • Biochemical Activity: 1
  • Co-localization: 1
  • FRET: 9
  • Reconstituted Complex: 7
  • Two-hybrid: 15
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 3
  • Phenotypic Enhancement: 56
  • Phenotypic Suppression: 13
  • Synthetic Growth Defect: 19
  • Synthetic Lethality: 15
  • Synthetic Rescue: 1
Sequence Information
ChrIV:1141163 to 1144837 | ORF Map | GBrowse
Gbrowse
Genetic position: 196 cM
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..3675 1141163..1144837 2008-06-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002743

MSN5 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for MSN5

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MSN5]

1) Akada R, et al.  (1996) Genetic relationships between the G protein beta gamma complex, Ste5p, Ste20p and Cdc42p: investigation of effector roles in the yeast pheromone response pathway. Genetics 143(1):103-17
2) Blondel M, et al.  (1999) Nuclear export of Far1p in response to pheromones requires the export receptor Msn5p/Ste21p. Genes Dev 13(17):2284-300
3) Kaffman A, et al.  (1998) The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus. Nature 396(6710):482-6
4) Alepuz PM, et al.  (1999) The Saccharomyces cerevisiae RanGTP-binding protein msn5p is involved in different signal transduction pathways. Genetics 153(3):1219-31
5) Yoshida K and Blobel G  (2001) The karyopherin Kap142p/Msn5p mediates nuclear import and nuclear export of different cargo proteins. J Cell Biol 152(4):729-40
6) Queralt E and Igual JC  (2003) Cell cycle activation of the Swi6p transcription factor is linked to nucleocytoplasmic shuttling. Mol Cell Biol 23(9):3126-40
7) Murthi A, et al.  (2009) Regulation of tRNA Bidirectional Nuclear-Cytoplasmic Trafficking in S. cerevisiae. Mol Biol Cell ()