Standard Name	SKP1 1
Systematic Name	YDR328C
Alias	MGO1
Feature Type	ORF, Verified
Description	Evolutionarily conserved kinetochore protein; part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase; protein abundance increases in response to DNA replication stress (2, 3, 4) Also known as: CBF3D 5
Name Description	Suppressor of Kinetochore Protein mutant 2

Chromosomal Location	ChrIV:1126018 to 1125434 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SKP1
Molecular Function
Manually curated	DNA replication origin binding (IPI) protein binding (IPI) contributes_to ubiquitin-protein ligase activity (IDA)
Biological Process
Manually curated	cytokinesis (IMP) G1/S transition of mitotic cell cycle (IMP) G2/M transition of mitotic cell cycle (IMP) kinetochore assembly (IDA, IMP) protein complex assembly (IDA) protein neddylation (IGI, IMP) protein ubiquitination involved in ubiquitin-dependent protein catabolic process (IDA) regulation of exit from mitosis (IMP, IPI) regulation of protein complex assembly (IPI) SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (IDA) septin ring assembly (IMP) vacuolar acidification (IGI, IMP)
Cellular Component
Manually curated	CBF3 complex (IDA, IGI, IPI) cytoplasm (IDA) kinetochore (TAS) nucleus (IDA) RAVE complex (IPI) SCF ubiquitin ligase complex (IDA, IPI)

Classical genetics
conditional	cell cycle progression in G1 phase: arrested cell cycle progression in G2 phase: abnormal cell cycle progression through the G2/M phase transition: arrested cellular morphology: abnormal colony sectoring: increased Dia2-Myc accumulation: decreased Dia2p accumulation: increased Cdc53p accumulation: decreased Cdc53p modification: decreased
null	inviable
reduction of function	Grr1-myc accumulation: increased
Large-scale survey
null	inviable
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	369 total interaction(s) for 137 unique genes/features.
Physical Interactions	Affinity Capture-MS: 109 Affinity Capture-RNA: 5 Affinity Capture-Western: 93 Biochemical Activity: 5 Co-crystal Structure: 1 Co-purification: 4 PCA: 3 Reconstituted Complex: 53 Two-hybrid: 48
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 2 Dosage Rescue: 15 Negative Genetic: 2 Phenotypic Enhancement: 1 Synthetic Growth Defect: 16 Synthetic Lethality: 8 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1126018 to 1125434 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..585 1126018..1125434 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002736