PEP7/YDR323C Summary 
| Standard Name | PEP7 1 |
|---|---|
| Systematic Name | YDR323C |
| Alias | VAC1 2 , VPL21 3 , VPS19 4 , 5 , VPT19 4 |
| Feature Type | ORF, Verified |
| Description | Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance (2, 6, 7, 8, 9, 10) |
| Name Description | carboxyPEPtidase Y-deficient 11 |
| Chromosomal Location | |
|---|---|
| Note: this feature is encoded on the Crick strand. | |
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| Genetic position: 192 cM |
Gene Ontology Annotations All PEP7 GO evidence and references
| View Computational GO annotations for PEP7 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated | |
| High-throughput |
Mutant phenotypes All PEP7 Phenotype evidence and references
interactions All PEP7 Interaction evidence and references
| 107 total interaction(s) for 85 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Resources |
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Expression Summary
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| Resources |
Protein Information All PEP7 Protein evidence and references
| Localization | |
|---|---|
| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
| Note: this feature is encoded on the Crick strand. | |||||||||||||
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| Genetic position: 192 cM | |||||||||||||
| Last Update | Coordinates: 2011-02-03 | Sequence: 1996-07-31 | ||||||||||||
| Subfeature details |
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| Retrieve sequences | |||||||||||||
Analyze Sequence
| S288C only | |
|---|---|
| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000002731 |
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References cited on this page View Complete Literature Guide for PEP7
| 1) | Jones, E. and Kolodny, M. (1985) Personal Communication, Mortimer Map Edition 9 |
| 2) | Weisman LS and Wickner W (1992) Molecular characterization of VAC1, a gene required for vacuole inheritance and vacuole protein sorting. J Biol Chem 267(1):618-23 |
| 3) | Raymond CK, et al. (1992) Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants. Mol Biol Cell 3(12):1389-402 |
| 4) | Robinson JS, et al. (1988) Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases. Mol Cell Biol 8(11):4936-48 |
| 5) | Rothman JH, et al. (1989) Characterization of genes required for protein sorting and vacuolar function in the yeast Saccharomyces cerevisiae. EMBO J 8(7):2057-65 |
| 6) | Webb GC, et al. (1997) Pep7p provides a novel protein that functions in vesicle-mediated transport between the yeast Golgi and endosome. Mol Biol Cell 8(5):871-95 |
| 7) | Conradt B, et al. (1992) In vitro reactions of vacuole inheritance in Saccharomyces cerevisiae. J Cell Biol 119(6):1469-79 |
| 8) | Peterson MR, et al. (1999) Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome. Curr Biol 9(3):159-62 |
| 9) | Burd CG, et al. (1997) A novel Sec18p/NSF-dependent complex required for Golgi-to-endosome transport in yeast. Mol Biol Cell 8(6):1089-104 |
| 10) | Tall GG, et al. (1999) The phosphatidylinositol 3-phosphate binding protein Vac1p interacts with a Rab GTPase and a Sec1p homologue to facilitate vesicle-mediated vacuolar protein sorting. Mol Biol Cell 10(6):1873-89 |
| 11) | Jones EW (1977) Proteinase mutants of Saccharomyces cerevisiae. Genetics 85(1):23-33 |
