Standard Name	MCM21 1
Systematic Name	YDR318W
Alias	CTF5 2
Feature Type	ORF, Verified
Description	Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2 (1, 3, 4)
Name Description	MiniChromosome Maintenance 5

Chromosomal Location	ChrIV:1103758 to 1104947 | ORF Map | GBrowse

	View Computational GO annotations for MCM21
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	chromosome segregation (IPI) establishment of mitotic sister chromatid cohesion (IMP)
Cellular Component
Manually curated	COMA complex (IDA) condensed nuclear chromosome kinetochore (IDA)

Classical genetics
null	chromosome/plasmid maintenance: abnormal colony sectoring: increased resistance to cincreasin: decreased resistance to benomyl: decreased resistance to bortezomib: decreased
unspecified	colony sectoring: increased
Large-scale survey
null	cell cycle progression in G1 phase: decreased duration colony sectoring: increased competitive fitness: decreased haploproficient resistance to fluconazole: increased resistance to fenpropimorph: increased resistance to cycloheximide: increased resistance to camptothecin: increased resistance to nickel sulfate: increased resistance to methyl methanesulfonate: decreased resistance to bleomycin: decreased resistance to dimethyl sulfoxide: decreased resistance to caffeine: decreased starvation resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	258 total interaction(s) for 126 unique genes/features.
Physical Interactions	Affinity Capture-MS: 31 Affinity Capture-Western: 14 Co-crystal Structure: 1 Co-fractionation: 3 Reconstituted Complex: 3 Two-hybrid: 10
Genetic Interactions	Dosage Lethality: 4 Dosage Rescue: 1 Negative Genetic: 118 Phenotypic Enhancement: 2 Phenotypic Suppression: 1 Positive Genetic: 5 Synthetic Growth Defect: 32 Synthetic Lethality: 31 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1103758 to 1104947 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2003-09-27
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..52 1103758..1103809 2011-02-03 2003-09-27 Intron 53..135 1103810..1103892 2011-02-03 2003-09-27 CDS 136..1190 1103893..1104947 2011-02-03 2003-09-27
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (53 - 135)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002726