SSF2/YDR312W Summary Help

Standard Name SSF2 1
Systematic Name YDR312W
Feature Type ORF, Verified
Description Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication (2, 3, 4)
Name Description Suppressor of ste4 (Four) 1
Chromosomal Location
ChrIV:1087581 to 1088942 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SSF2 GO evidence and references
  View Computational GO annotations for SSF2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Large-scale survey
null
overexpression
Resources
63 total interaction(s) for 53 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • Biochemical Activity: 8
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Lethality: 2
  • Dosage Rescue: 2
  • Negative Genetic: 30
  • Phenotypic Suppression: 1
  • Positive Genetic: 3
  • Synthetic Lethality: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 453
Molecular Weight (Da) 51,856
Isoelectric Point (pI) 9.79
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1087581 to 1088942 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1362 1087581..1088942 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002720
References cited on this page View Complete Literature Guide for SSF2
1) Yu Y and Hirsch JP  (1995) An essential gene pair in Saccharomyces cerevisiae with a potential role in mating. DNA Cell Biol 14(5):411-8
2) Fatica A, et al.  (2002) Ssf1p prevents premature processing of an early pre-60S ribosomal particle. Mol Cell 9(2):341-51
3) Bogengruber E, et al.  (2003) Functional analysis in yeast of the Brix protein superfamily involved in the biogenesis of ribosomes. FEMS Yeast Res 3(1):35-43
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61