TFB1/YDR311W Summary Help

Standard Name TFB1
Systematic Name YDR311W
Feature Type ORF, Verified
Description Subunit of TFIIH and nucleotide excision repair factor 3 complexes; required for nucleotide excision repair, target for transcriptional activators; relocalizes to the cytosol in response to hypoxia (1, 2, 3)
Name Description Transcription initiation Factor IIB
Chromosomal Location
ChrIV:1085065 to 1086993 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All TFB1 GO evidence and references
  View Computational GO annotations for TFB1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Large-scale survey
conditional
null
overexpression
reduction of function
unspecified
Resources
116 total interaction(s) for 72 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 30
  • Affinity Capture-Western: 6
  • Co-crystal Structure: 2
  • Co-purification: 15
  • PCA: 3
  • Reconstituted Complex: 9
  • Two-hybrid: 11

Genetic Interactions
  • Negative Genetic: 26
  • Phenotypic Suppression: 1
  • Positive Genetic: 2
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 4
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 642
Molecular Weight (Da) 72,894
Isoelectric Point (pI) 6.89
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1085065 to 1086993 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1929 1085065..1086993 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002719
References cited on this page View Complete Literature Guide for TFB1
1) Prakash S and Prakash L  (2000) Nucleotide excision repair in yeast. Mutat Res 451(1-2):13-24
2) Lee TI and Young RA  (2000) Transcription of eukaryotic protein-coding genes. Annu Rev Genet 34:77-137
3) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30