SUM1/YDR310C Summary Help

SUM1 BASIC INFORMATION

Standard Name SUM1 1
Systematic Name YDR310C
Feature Type ORF, Verified
Description Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint (1, 2, 3, 4, 5, 6)
Name Description SUppresor of Mar1-1 1
GO Annotations All SUM1 GO evidence and references
    View Computational GO annotations for SUM1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Binding motifs SUM1 Transcription Factor Binding Sites and References
  • AGYGWCACAAAAK
  • GYGWCASWAAW
Regulatory modules predicted: stressResponse ( 469 )
Mutant Phenotype All SUM1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions SUM1 All interactions details and references
77 total interaction(s) for 55 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 8
  • Protein-RNA: 1
  • Two-hybrid: 4
Genetic Interactions
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 4
  • Synthetic Growth Defect: 13
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 24
  • Synthetic Rescue: 13
Sequence Information
ChrIV:1084313 to 1081125 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..3189 1084313..1081125 2008-06-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002718

SUM1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SUM1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SUM1]

1) Klar AJ, et al.  (1985) SUM1, an apparent positive regulator of the cryptic mating-type loci in Saccharomyces cerevisiae. Genetics 111(4):745-58
2) Xie J, et al.  (1999) Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae. EMBO J 18(22):6448-54
3) Laurenson P and Rine J  (1991) SUM1-1: a suppressor of silencing defects in Saccharomyces cerevisiae. Genetics 129(3):685-96
4) Lindgren A, et al.  (2000) The pachytene checkpoint in Saccharomyces cerevisiae requires the Sum1 transcriptional repressor. EMBO J 19(23):6489-97
5) Irlbacher H, et al.  (2005) Control of replication initiation and heterochromatin formation in Saccharomyces cerevisiae by a regulator of meiotic gene expression. Genes Dev 19(15):1811-22
6) Askree SH, et al.  (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63