SUM1/YDR310C Summary Help

Standard Name SUM1 1
Systematic Name YDR310C
Feature Type ORF, Verified
Description Transcriptional repressor that regulates middle-sporulation genes; required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint (1, 2, 3, 4, 5, 6)
Name Description SUppresor of Mar1-1 1
Chromosomal Location
ChrIV:1084316 to 1081128 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SUM1 GO evidence and references
  View Computational GO annotations for SUM1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 127 genes
Regulators 4 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
overexpression
Resources
346 total interaction(s) for 227 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 21
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 11
  • Biochemical Activity: 1
  • Protein-RNA: 1
  • Two-hybrid: 8

Genetic Interactions
  • Dosage Rescue: 10
  • Negative Genetic: 101
  • Phenotypic Enhancement: 98
  • Phenotypic Suppression: 8
  • Positive Genetic: 30
  • Synthetic Growth Defect: 20
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 20
  • Synthetic Rescue: 14

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,062
Molecular Weight (Da) 118,200
Isoelectric Point (pI) 6.11
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1084316 to 1081128 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3189 1084316..1081128 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002718
References cited on this page View Complete Literature Guide for SUM1
1) Klar AJ, et al.  (1985) SUM1, an apparent positive regulator of the cryptic mating-type loci in Saccharomyces cerevisiae. Genetics 111(4):745-58
2) Xie J, et al.  (1999) Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae. EMBO J 18(22):6448-54
3) Laurenson P and Rine J  (1991) SUM1-1: a suppressor of silencing defects in Saccharomyces cerevisiae. Genetics 129(3):685-96
4) Lindgren A, et al.  (2000) The pachytene checkpoint in Saccharomyces cerevisiae requires the Sum1 transcriptional repressor. EMBO J 19(23):6489-97
5) Irlbacher H, et al.  (2005) Control of replication initiation and heterochromatin formation in Saccharomyces cerevisiae by a regulator of meiotic gene expression. Genes Dev 19(15):1811-22
6) Askree SH, et al.  (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63
7) Pierce M, et al.  (2003) Sum1 and Ndt80 proteins compete for binding to middle sporulation element sequences that control meiotic gene expression. Mol Cell Biol 23(14):4814-25
8) Zhu C, et al.  (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19(4):556-66
9) Harbison CT, et al.  (2004) Transcriptional regulatory code of a eukaryotic genome. Nature 431(7004):99-104
10) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87