SUM1/YDR310C Summary Help

Standard Name SUM1 1
Systematic Name YDR310C
Feature Type ORF, Verified
Description Transcriptional repressor that regulates middle-sporulation genes; required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint (1, 2, 3, 4, 5, 6)
Name Description SUppresor of Mar1-1 1
Chromosomal Location
ChrIV:1084316 to 1081128 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All SUM1 GO evidence and references
  View Computational GO annotations for SUM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 127 genes
Regulators 4 genes
Classical genetics
Large-scale survey
346 total interaction(s) for 227 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 21
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 11
  • Biochemical Activity: 1
  • Protein-RNA: 1
  • Two-hybrid: 8

Genetic Interactions
  • Dosage Rescue: 10
  • Negative Genetic: 101
  • Phenotypic Enhancement: 98
  • Phenotypic Suppression: 8
  • Positive Genetic: 30
  • Synthetic Growth Defect: 20
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 20
  • Synthetic Rescue: 14

Expression Summary
Length (a.a.) 1,062
Molecular Weight (Da) 118,200
Isoelectric Point (pI) 6.11
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIV:1084316 to 1081128 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..3189 1084316..1081128 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002718
References cited on this page View Complete Literature Guide for SUM1
1) Klar AJ, et al.  (1985) SUM1, an apparent positive regulator of the cryptic mating-type loci in Saccharomyces cerevisiae. Genetics 111(4):745-58
2) Xie J, et al.  (1999) Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae. EMBO J 18(22):6448-54
3) Laurenson P and Rine J  (1991) SUM1-1: a suppressor of silencing defects in Saccharomyces cerevisiae. Genetics 129(3):685-96
4) Lindgren A, et al.  (2000) The pachytene checkpoint in Saccharomyces cerevisiae requires the Sum1 transcriptional repressor. EMBO J 19(23):6489-97
5) Irlbacher H, et al.  (2005) Control of replication initiation and heterochromatin formation in Saccharomyces cerevisiae by a regulator of meiotic gene expression. Genes Dev 19(15):1811-22
6) Askree SH, et al.  (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63
7) Pierce M, et al.  (2003) Sum1 and Ndt80 proteins compete for binding to middle sporulation element sequences that control meiotic gene expression. Mol Cell Biol 23(14):4814-25
8) Zhu C, et al.  (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19(4):556-66
9) Harbison CT, et al.  (2004) Transcriptional regulatory code of a eukaryotic genome. Nature 431(7004):99-104
10) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87