HNT2/YDR305C Summary Help

Standard Name HNT2
Systematic Name YDR305C
Alias APH1
Feature Type ORF, Verified
Description Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins (1, 2, 3)
Name Description Histidine triad NucleoTide-binding
Chromosomal Location
ChrIV:1073488 to 1072746 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All HNT2 GO evidence and references
  View Computational GO annotations for HNT2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 2 genes
Resources
Large-scale survey
null
Resources
39 total interaction(s) for 30 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Co-purification: 1
  • PCA: 1

Genetic Interactions
  • Negative Genetic: 29
  • Positive Genetic: 4
  • Synthetic Growth Defect: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 217
Molecular Weight (Da) 24,784
Isoelectric Point (pI) 9.92
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1073488 to 1072746 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..87 1073488..1073402 2011-02-03 1996-07-31
Intron 88..176 1073401..1073313 2011-02-03 1996-07-31
CDS 177..743 1073312..1072746 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002713
References cited on this page View Complete Literature Guide for HNT2
1) Brevet A, et al.  (1991) Isolation and characterization of a dinucleoside triphosphatase from Saccharomyces cerevisiae. J Bacteriol 173(17):5275-9
2) Chen J, et al.  (1998) Control of 5',5'-dinucleoside triphosphate catabolism by APH1, a Saccharomyces cerevisiae analog of human FHIT. J Bacteriol 180(9):2345-9
3) Rubio-Texeira M, et al.  (2002) Control of dinucleoside polyphosphates by the FHIT-homologous HNT2 gene, adenine biosynthesis and heat shock in Saccharomyces cerevisiae. BMC Mol Biol 3():7