Standard Name	RSC3
Systematic Name	YDR303C
Feature Type	ORF, Verified
Description	Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; RSC3 has a paralog, RSC30, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	Remodel the Structure of Chromatin 5

Chromosomal Location	ChrIV:1071386 to 1068729 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for RSC3
Molecular Function
Manually curated	DNA binding (ISS) contributes_to DNA translocase activity (IDA)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	ATP-dependent chromatin remodeling (IDA) G1/S transition of mitotic cell cycle (IMP) G2/M transition of mitotic cell cycle (IMP) nucleosome disassembly (IDA) nucleosome positioning (IMP) regulation of cell cycle (IGI, IMP) regulation of nuclear cell cycle DNA replication (IGI) regulation of transcription, DNA-dependent (IMP) transcription elongation from RNA polymerase II promoter (IDA)
Cellular Component
Manually curated	RSC complex (IDA)
High-throughput	nucleus (IDA)

Binding motifs	CGCGB 6 [Search intergenic regions for CGCGB] CGCGCGC 7 [Search intergenic regions for CGCGCGC]
Regulatory modules	predicted: cellcycle (239)
Resources	ScerTF | UniProbe | YeTFaSCo

Classical genetics
null	bud neck morphology: abnormal cytokinesis: abnormal viable
repressible	cell cycle progression in G1 phase: arrested cell cycle progression through the G2/M phase transition: arrested
Large-scale survey
conditional	colony sectoring: increased
null	inviable
overexpression	vegetative growth: decreased rate vegetative growth: decreased
reduction of function	competitive fitness: increased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	155 total interaction(s) for 57 unique genes/features.
Physical Interactions	Affinity Capture-MS: 120 Affinity Capture-RNA: 2 Affinity Capture-Western: 10 Co-purification: 3 Reconstituted Complex: 4 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 5 Phenotypic Enhancement: 1 Synthetic Lethality: 7 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1071386 to 1068729 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2658 1071386..1068729 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002711