RSC3/YDR303C Summary

RSC3 BASIC INFORMATION

Standard Name	RSC3
Systematic Name	YDR303C
Feature Type	ORF, Verified
Description	Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p (1, 2, 3)
Name Description	Remodel the Structure of Chromatin

GO Annotations	All RSC3 GO evidence and references
	View Computational GO annotations for RSC3
Molecular Function
Manually curated	DNA binding (ISS) contributes_to DNA-dependent ATPase activity (IDA)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	ATP-dependent chromatin remodeling (IDA) G1/S transition of mitotic cell cycle (IMP) G2/M transition of mitotic cell cycle (IMP) nucleosome disassembly (IDA) regulation of cell cycle (IGI, IMP) regulation of DNA replication during S phase (IGI) regulation of transcription, DNA-dependent (IMP) RNA elongation from RNA polymerase II promoter (IDA)
Cellular Component
Manually curated	RSC complex (IDA)
High-throughput	nucleus (IDA)

Regulatory Role
Regulatory modules	predicted: cellcycle ( 239 )

Mutant Phenotype	All RSC3 Phenotype details and references
Classical genetics
null	bud neck morphology: abnormal cytokinesis: abnormal viable
repressible	cell cycle progression in G1 phase: arrested cell cycle progression through the G2/M phase transition: arrested
Large-scale survey
null	inviable
overexpression	vegetative growth: decreased

Interactions	RSC3 All interactions details and references
	137 total interaction(s) for 47 unique genes/features.
Physical Interactions	Affinity Capture-MS: 112 Affinity Capture-RNA: 2 Affinity Capture-Western: 9 Co-purification: 3 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 4 Phenotypic Enhancement: 1 Synthetic Lethality: 5

Sequence Information

ChrIV:1071383 to 1068726 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2658	1071383..1068726	2008-06-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002711

RSC3 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RSC3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RSC3]

1)	Lorch Y, et al. (1998) Activated RSC-nucleosome complex and persistently altered form of the nucleosome. Cell 94(1):29-34
2)	Neely KE and Workman JL (2002) The complexity of chromatin remodeling and its links to cancer. Biochim Biophys Acta 1603(1):19-29
3)	Campsteijn C, et al. (2007) Reverse genetic analysis of the yeast RSC chromatin remodeler reveals a role for RSC3 and SNF5 homolog 1 in ploidy maintenance. PLoS Genet 3(6):e92

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