MHR1/YDR296W Summary Help

Standard Name MHR1
Systematic Name YDR296W
Alias XTC1 1
Feature Type ORF, Verified
Description Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress (2, 3, 4, 5)
Name Description Mitochondrial Homologous DNA Recombination
Chromosomal Location
ChrIV:1055212 to 1055892 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MHR1 GO evidence and references
  View Computational GO annotations for MHR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
conditional
null
Large-scale survey
null
Resources
78 total interaction(s) for 51 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 60
  • Affinity Capture-RNA: 5
  • PCA: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 3

Genetic Interactions
  • Phenotypic Enhancement: 5
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 226
Molecular Weight (Da) 26,895
Isoelectric Point (pI) 10.3
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1055212 to 1055892 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..681 1055212..1055892 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002704
References cited on this page View Complete Literature Guide for MHR1
1) Emili A, et al.  (1998) A novel yeast protein influencing the response of RNA polymerase II to transcriptional activators. Proc Natl Acad Sci U S A 95(19):11122-7
2) Ling F, et al.  (2000) A role for MHR1, a gene required for mitochondrial genetic recombination, in the repair of damage spontaneously introduced in yeast mtDNA. Nucleic Acids Res 28(24):4956-63
3) Traven A, et al.  (2002) The yeast protein Xtc1 functions as a direct transcriptional repressor. Nucleic Acids Res 30(11):2358-64
4) Ling F and Shibata T  (2002) Recombination-dependent mtDNA partitioning: in vivo role of Mhr1p to promote pairing of homologous DNA. EMBO J 21(17):4730-40
5) Hori A, et al.  (2009) Reactive oxygen species regulate DNA copy number in isolated yeast mitochondria by triggering recombination-mediated replication. Nucleic Acids Res 37(3):749-61