Standard Name	HDA2
Systematic Name	YDR295C
Alias	PLO2
Feature Type	ORF, Verified
Description	Subunit of the HDA1 histone deacetylase complex; possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance; relocalizes to the cytosol in response to hypoxia (1, 2, 3)
Name Description	Histone DeAcetylase 1

Chromosomal Location	ChrIV:1054647 to 1052623 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for HDA2
Molecular Function
Manually curated	chromatin binding (IDA) DNA binding (IDA) contributes_to histone deacetylase activity (IDA)
Biological Process
Manually curated	gene silencing by RNA (IMP) gene silencing involved in chronological cell aging (IGI, IMP) histone deacetylation (IDA, IMP) negative regulation of transcription from RNA polymerase II promoter (IMP)
Cellular Component
Manually curated	cytosol (IDA) HDA1 complex (IDA, IPI) nucleus (IDA)
High-throughput	nucleus (IDA)

Classical genetics
null	chronological lifespan: decreased Pot1-GFP accumulation: decreased histone H2B and H3 modification: increased silencing: increased viable
Large-scale survey
null	acid pH resistance: decreased polyphosphate accumulation: abnormal competitive fitness: decreased filamentous growth: decreased haploinsufficient invasive growth: absent metal resistance: increased resistance to 2,4-dichlorophenol: decreased resistance to neomycin: decreased resistance to ethanol: decreased resistance to nickel sulfate: decreased resistance to hydroxyurea: increased resistance to pentachlorophenol: decreased resistance to BPS: decreased resistance to sodium arsenite: decreased resistance to cycloheximide: decreased stress resistance: decreased telomere length: decreased vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	295 total interaction(s) for 241 unique genes/features.
Physical Interactions	Affinity Capture-MS: 14 Affinity Capture-Western: 3 Biochemical Activity: 2 Reconstituted Complex: 2 Two-hybrid: 128
Genetic Interactions	Dosage Lethality: 1 Phenotypic Enhancement: 2 Phenotypic Suppression: 2 Synthetic Growth Defect: 40 Synthetic Lethality: 10 Synthetic Rescue: 91
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1054647 to 1052623 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	This feature is contained within: 70360
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2025 1054647..1052623 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002703