HDA2/YDR295C Summary

HDA2 BASIC INFORMATION

Standard Name	HDA2
Systematic Name	YDR295C
Alias	PLO2
Feature Type	ORF, Verified
Description	Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance (1, 2)
Name Description	Histone DeAcetylase 1

GO Annotations	All HDA2 GO evidence and references
	View Computational GO annotations for HDA2
Molecular Function
Manually curated	chromatin binding (IDA) DNA binding (IDA) contributes_to histone deacetylase activity (IDA)
Biological Process
Manually curated	gene silencing by RNA (IMP) gene silencing involved in chronological cell aging (IGI, IMP) histone deacetylation (IDA, IMP) negative regulation of transcription from RNA polymerase II promoter (IMP)
Cellular Component
Manually curated	HDA1 complex (IDA, IPI)
High-throughput	nucleus (IDA)

Mutant Phenotype	All HDA2 Phenotype details and references
Classical genetics
null	chronological lifespan: decreased histone H2B and H3 modification: increased silencing: increased viable
Large-scale survey
null	acid pH resistance: decreased polyphosphate accumulation: abnormal filamentous growth: decreased invasive growth: absent resistance to hydroxyurea: increased resistance to nickel sulfate: decreased telomere length: decreased viable

Interactions	HDA2 All interactions details and references
	108 total interaction(s) for 86 unique genes/features.
Physical Interactions	Affinity Capture-MS: 14 Affinity Capture-Western: 4 Biochemical Activity: 2 Reconstituted Complex: 2 Two-hybrid: 12
Genetic Interactions	Synthetic Growth Defect: 40 Synthetic Lethality: 9 Synthetic Rescue: 25

Sequence Information

ChrIV:1054644 to 1052620 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2025	1054644..1052620	2008-06-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002703

HDA2 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for HDA2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HDA2]

1)	Wu J, et al. (2001) HDA2 and HDA3 are related proteins that interact with and are essential for the activity of the yeast histone deacetylase HDA1. Proc Natl Acad Sci U S A 98(8):4391-6
2)	Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63

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