SSD1/YDR293C Summary Help

SSD1 BASIC INFORMATION

Standard Name SSD1 1
Systematic Name YDR293C
Alias CLA1 , MCS1 , RLT1 , SRK1
Feature Type ORF, Verified
Description Protein with a role in maintenance of cellular integrity, interacts with components of the TOR pathway; ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence (2, 3, 4)
Name Description Suppressor of SIT4 Deletion 1, 5
GO Annotations All SSD1 GO evidence and references
    View Computational GO annotations for SSD1
Molecular Function
Manually curated
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
Mutant Phenotype All SSD1 Phenotype details and references
Classical genetics
null
reduction of function
Large-scale survey
null
overexpression
Interactions SSD1 All interactions details and references
257 total interaction(s) for 186 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 18
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 2
  • Biochemical Activity: 19
  • PCA: 13
  • Reconstituted Complex: 1
  • Two-hybrid: 1
Genetic Interactions
  • Dosage Rescue: 29
  • Phenotypic Enhancement: 116
  • Phenotypic Suppression: 14
  • Synthetic Growth Defect: 7
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 20
  • Synthetic Rescue: 14
Sequence Information
ChrIV:1049389 to 1045637 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 176 cM
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..3753 1049389..1045637 2008-06-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002701

SSD1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SSD1

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
ZDS2Nomenclature conflictMCS1 has been used to refer to both ZDS2/YML109W, whose gene product is involved in silencing, and SSD1/YDR293C, whose gene product is involved in cell wall integrity.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SSD1]

1) Sutton A, et al.  (1991) The SIT4 protein phosphatase functions in late G1 for progression into S phase. Mol Cell Biol 11(4):2133-48
2) Kaeberlein M and Guarente L  (2002) Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics 160(1):83-95
3) Wheeler RT, et al.  (2003) A Saccharomyces cerevisiae mutant with increased virulence. Proc Natl Acad Sci U S A 100(5):2766-70
4) Reinke A, et al.  (2004) TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae. J Biol Chem 279(15):14752-62
5) Stettler S, et al.  (1993) A general suppressor of RNA polymerase I, II and III mutations in Saccharomyces cerevisiae. Mol Gen Genet 239(1-2):169-76