HRQ1/YDR291W Summary Help

Standard Name HRQ1 1
Systematic Name YDR291W
Feature Type ORF, Verified
Description 3'-5' DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; acts with Rad4p in nucleotide-excision repair; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome (RTS) (1, 2, 3)
Name Description Homologous to RecQ protein 1
Chromosomal Location
ChrIV:1039728 to 1042961 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HRQ1 GO evidence and references
  View Computational GO annotations for HRQ1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Classical genetics
null
Large-scale survey
null
Resources
142 total interaction(s) for 136 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
  • Co-purification: 1
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 98
  • Phenotypic Enhancement: 1
  • Positive Genetic: 28
  • Synthetic Growth Defect: 8
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,077
Molecular Weight (Da) 123,548
Isoelectric Point (pI) 6.65
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1039728 to 1042961 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3234 1039728..1042961 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002699
References cited on this page View Complete Literature Guide for HRQ1
1) Barea F, et al.  (2008) In silico analyses of a new group of fungal and plant RecQ4-homologous proteins. Comput Biol Chem 32(5):349-58
2) Kwon SH, et al.  (2012) Saccharomyces cerevisiae Hrq1 requires a long 3'-tailed DNA substrate for helicase activity. Biochem Biophys Res Commun 427(3):623-8
3) Choi DH, et al.  (2014) Hrq1 facilitates nucleotide excision repair of DNA damage induced by 4-nitroquinoline-1-oxide and cisplatin in Saccharomyces cerevisiae. J Microbiol 52(4):292-8