ZIP1/YDR285W Summary Help

Standard Name ZIP1 1
Systematic Name YDR285W
Feature Type ORF, Verified
Description Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; required for meiotic recombination between non-allelc sites; potential Cdc28p substrate (2, 3, 4, 5, 6)
Name Description molecular ZIPper 1
Chromosomal Location
ChrIV:1032436 to 1035063 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ZIP1 GO evidence and references
  View Computational GO annotations for ZIP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
null
Resources
91 total interaction(s) for 68 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Biochemical Activity: 2
  • Co-purification: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 42

Genetic Interactions
  • Dosage Rescue: 5
  • Negative Genetic: 6
  • Phenotypic Enhancement: 10
  • Phenotypic Suppression: 6
  • Synthetic Growth Defect: 3
  • Synthetic Rescue: 8

Resources
Expression Summary
histogram
Resources
Length (a.a.) 875
Molecular Weight (Da) 100,034
Isoelectric Point (pI) 6.81
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1032436 to 1035063 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2628 1032436..1035063 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002693
References cited on this page View Complete Literature Guide for ZIP1
1) Sym M, et al.  (1993) ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis. Cell 72(3):365-78
2) Dong H and Roeder GS  (2000) Organization of the yeast Zip1 protein within the central region of the synaptonemal complex. J Cell Biol 148(3):417-26
3) Storlazzi A, et al.  (1996) Synaptonemal complex (SC) component Zip1 plays a role in meiotic recombination independent of SC polymerization along the chromosomes. Proc Natl Acad Sci U S A 93(17):9043-8
4) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
5) Tsubouchi T and Roeder GS  (2005) A synaptonemal complex protein promotes homology-independent centromere coupling. Science 308(5723):870-3
6) Shinohara M and Shinohara A  (2013) Multiple Pathways Suppress Non-Allelic Homologous Recombination during Meiosis in Saccharomyces cerevisiae. PLoS One 8(4):e63144