MTH1/YDR277C Summary Help

MTH1 BASIC INFORMATION

Standard Name MTH1 1
Systematic Name YDR277C
Alias BPC1 , DGT1 2 , HTR1 3
Feature Type ORF, Verified
Description Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation (1, 4, 5)
Name Description MSN Three Homolog 6
GO Annotations All MTH1 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All MTH1 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Interactions MTH1 All interactions details and references
  View additional details at BioGRID
66 total interaction(s) for 48 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3
  • Reconstituted Complex: 1
  • Two-hybrid: 22
Genetic Interactions
  • Dosage Rescue: 8
  • Negative Genetic: 21
  • Phenotypic Enhancement: 3
  • Synthetic Growth Defect: 3
  • Synthetic Rescue: 4
Sequence Information
ChrIV:1015699 to 1014398 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1302 1015699..1014398 2008-06-05 1996-07-31
Post-translational Modifications PhosphoGRID | PhosphoPep Database
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002685

MTH1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for MTH1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MTH1]

1) Lafuente MJ, et al.  (2000) Mth1 receives the signal given by the glucose sensors Snf3 and Rgt2 in Saccharomyces cerevisiae. Mol Microbiol 35(1):161-72
2) Gamo FJ, et al.  (1994) The mutation DGT1-1 decreases glucose transport and alleviates carbon catabolite repression in Saccharomyces cerevisiae. J Bacteriol 176(24):7423-9
3) Schulte F, et al.  (2000) The HTR1 gene is a dominant negative mutant allele of MTH1 and blocks Snf3- and Rgt2-dependent glucose signaling in yeast. J Bacteriol 182(2):540-2
4) Lakshmanan J, et al.  (2003) Repression of transcription by Rgt1 in the absence of glucose requires Std1 and Mth1. Curr Genet 44(1):19-25
5) Moriya H and Johnston M  (2004) Glucose sensing and signaling in Saccharomyces cerevisiae through the Rgt2 glucose sensor and casein kinase I. Proc Natl Acad Sci U S A 101(6):1572-7
6) Hubbard EJ, et al.  (1994) Dosage-dependent modulation of glucose repression by MSN3 (STD1) in Saccharomyces cerevisiae. Mol Cell Biol 14(3):1972-8