MTH1/YDR277C Summary Help

Standard Name MTH1 1
Systematic Name YDR277C
Alias BPC1 , DGT1 2 , HTR1 3
Feature Type ORF, Verified
Description Negative regulator of the glucose-sensing signal transduction pathway; required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation; MTH1 has a paralog, STD1, that arose from the whole genome duplication (1, 4, 5, 6)
Name Description MSN Three Homolog 7
Chromosomal Location
ChrIV:1015702 to 1014401 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All MTH1 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
91 total interaction(s) for 66 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 3
  • Reconstituted Complex: 2
  • Two-hybrid: 23

Genetic Interactions
  • Dosage Lethality: 2
  • Dosage Rescue: 8
  • Negative Genetic: 31
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 2
  • Synthetic Growth Defect: 4
  • Synthetic Rescue: 8

Resources
Expression Summary
histogram
Resources
Length (a.a.) 433
Molecular Weight (Da) 49,060
Isoelectric Point (pI) 9.79
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1015702 to 1014401 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1302 1015702..1014401 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002685
References cited on this page View Complete Literature Guide for MTH1
1) Lafuente MJ, et al.  (2000) Mth1 receives the signal given by the glucose sensors Snf3 and Rgt2 in Saccharomyces cerevisiae. Mol Microbiol 35(1):161-72
2) Gamo FJ, et al.  (1994) The mutation DGT1-1 decreases glucose transport and alleviates carbon catabolite repression in Saccharomyces cerevisiae. J Bacteriol 176(24):7423-9
3) Schulte F, et al.  (2000) The HTR1 gene is a dominant negative mutant allele of MTH1 and blocks Snf3- and Rgt2-dependent glucose signaling in yeast. J Bacteriol 182(2):540-2
4) Lakshmanan J, et al.  (2003) Repression of transcription by Rgt1 in the absence of glucose requires Std1 and Mth1. Curr Genet 44(1):19-25
5) Moriya H and Johnston M  (2004) Glucose sensing and signaling in Saccharomyces cerevisiae through the Rgt2 glucose sensor and casein kinase I. Proc Natl Acad Sci U S A 101(6):1572-7
6) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
7) Hubbard EJ, et al.  (1994) Dosage-dependent modulation of glucose repression by MSN3 (STD1) in Saccharomyces cerevisiae. Mol Cell Biol 14(3):1972-8