DON1/YDR273W Summary Help

Standard Name DON1 1
Systematic Name YDR273W
Feature Type ORF, Verified
Description Meiosis-specific component of the spindle pole body; part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; DON1 has a paralog, CUE5, that arose from the whole genome (1, 2, 3, 4)
Name Description DONut 1
Chromosomal Location
ChrIV:1010176 to 1011273 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All DON1 GO evidence and references
  View Computational GO annotations for DON1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 48 genes
Resources
Large-scale survey
null
Resources
20 total interaction(s) for 20 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 6
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 365
Molecular Weight (Da) 40,162
Isoelectric Point (pI) 4.59
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1010176 to 1011273 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1098 1010176..1011273 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002681
References cited on this page View Complete Literature Guide for DON1
1) Knop M and Strasser K  (2000) Role of the spindle pole body of yeast in mediating assembly of the prospore membrane during meiosis. EMBO J 19(14):3657-67
2) Moreno-Borchart AC, et al.  (2001) Prospore membrane formation linked to the leading edge protein (LEP) coat assembly. EMBO J 20(24):6946-57
3) Nickas ME and Neiman AM  (2002) Ady3p links spindle pole body function to spore wall synthesis in Saccharomyces cerevisiae. Genetics 160(4):1439-50
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61