DIN7/YDR263C Summary Help

Standard Name DIN7 1
Systematic Name YDR263C
Alias DIN3
Feature Type ORF, Verified
Description Mitochondrial nuclease functioning in DNA repair and replication; modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination; DIN7 has a paralog, EXO1, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description DNA Damage INducible 1
Chromosomal Location
ChrIV:995534 to 994242 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All DIN7 GO evidence and references
  View Computational GO annotations for DIN7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Classical genetics
Large-scale survey
14 total interaction(s) for 14 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 2

Genetic Interactions
  • Negative Genetic: 6
  • Phenotypic Enhancement: 2
  • Positive Genetic: 1
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 430
Molecular Weight (Da) 49,034
Isoelectric Point (pI) 10.02
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIV:995534 to 994242 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1293 995534..994242 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002671
References cited on this page View Complete Literature Guide for DIN7
1) Mieczkowski PA, et al.  (1997) Characterization of a novel DNA damage-inducible gene of Saccharomyces cerevisiae, DIN7, which is a structural homolog of the RAD2 and RAD27 DNA repair genes. Mol Gen Genet 253(6):655-65
2) Qiu J, et al.  (1998) Saccharomyces cerevisiae exonuclease-1 plays a role in UV resistance that is distinct from nucleotide excision repair. Nucleic Acids Res 26(13):3077-83
3) Fikus MU, et al.  (2000) The product of the DNA damage-inducible gene of Saccharomyces cerevisiae, DIN7, specifically functions in mitochondria. Genetics 154(1):73-81
4) Koprowski P, et al.  (2003) Enhanced expression of the DNA damage-inducible gene DIN7 results in increased mutagenesis of mitochondrial DNA in Saccharomyces cerevisiae. Mol Genet Genomics 269(5):632-9
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61