Standard Name	YAP6 1
Systematic Name	YDR259C
Alias	HAL7 2
Feature Type	ORF, Verified
Description	Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog, CIN5, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description	Yeast homolog of AP-1 1

Chromosomal Location	ChrIV:975782 to 974631 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for YAP6
Molecular Function
Manually curated	sequence-specific DNA binding RNA polymerase II transcription factor activity (IDA) sequence-specific DNA binding transcription factor recruiting transcription factor activity (IPI)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	negative regulation of transcription from RNA polymerase II promoter (IMP, IPI) positive regulation of transcription from RNA polymerase II promoter (IMP, ISS)
Cellular Component
Manually curated	nucleus (IDA)

Binding motifs	Predicted YAP6 Binding Site Locations
	TTANGTNA 6 [Search intergenic regions for TTANGTNA]
Regulatory modules	predicted: stressResponse (499, 427, 415)
Resources	ScerTF | UniProbe | YEASTRACT | YeTFaSCo

Classical genetics
overexpression	resistance to methyl methanesulfonate: increased resistance to mitomycin C: increased resistance to cisplatin: increased
Large-scale survey
null	competitive fitness: decreased haploinsufficient Fus-Mid-GFP distribution: abnormal sporulation: normal viable
overexpression	filamentous growth: increased vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	61 total interaction(s) for 59 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 2 Affinity Capture-Western: 2 Biochemical Activity: 7 Two-hybrid: 38
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 1 Dosage Rescue: 1 Negative Genetic: 8 Synthetic Growth Defect: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:975782 to 974631 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1152 975782..974631 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002667