Standard Name	VHS1 1
Systematic Name	YDR247W
Feature Type	ORF, Verified
Description	Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; VHS1 has a paralog, SKS1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	Viable in a Hal3 Sit4 background 1

Chromosomal Location	ChrIV:956013 to 957398 | ORF Map | GBrowse

	View Computational GO annotations for VHS1
Molecular Function
Manually curated	protein kinase activity (ISS) protein serine/threonine kinase activity (ISS)
High-throughput	protein kinase activity (IDA)
Biological Process
Manually curated	G1/S transition of mitotic cell cycle (IGI) protein phosphorylation (ISS)
High-throughput	protein phosphorylation (IDA)
Cellular Component
High-throughput	cytoplasm (IDA)

Classical genetics
null	glycogen accumulation: increased
Large-scale survey
null	glycogen accumulation: increased competitive fitness: increased haploproficient hyperosmotic stress resistance: decreased replicative lifespan: increased resistance to tunicamycin: decreased resistance to 1,4-dithiothreitol: decreased resistance to benzo[a]pyrene: increased sporulation: normal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	225 total interaction(s) for 195 unique genes/features.
Physical Interactions	Affinity Capture-MS: 38 Affinity Capture-RNA: 1 Affinity Capture-Western: 6 Biochemical Activity: 15 Reconstituted Complex: 18
Genetic Interactions	Dosage Growth Defect: 22 Dosage Rescue: 2 Negative Genetic: 116 Positive Genetic: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:956013 to 957398 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1386 956013..957398 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002655