TRS23/YDR246W Summary Help

Standard Name TRS23 1
Systematic Name YDR246W
Feature Type ORF, Verified
Description Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); human homolog is TRAPPC4 (1, 2, 3, 4)
Name Description TRapp Subunit 1
Chromosomal Location
ChrIV:954288 to 954947 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All TRS23 GO evidence and references
  View Computational GO annotations for TRS23
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
conditional
reduction of function
Large-scale survey
conditional
null
reduction of function
Resources
53 total interaction(s) for 17 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 18
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 10
  • Co-fractionation: 5
  • Co-purification: 2
  • Two-hybrid: 7

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 2
  • Synthetic Growth Defect: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 219
Molecular Weight (Da) 24,863
Isoelectric Point (pI) 9.54
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:954288 to 954947 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..660 954288..954947 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002654
References cited on this page View Complete Literature Guide for TRS23
1) Sacher M, et al.  (2000) Identification and characterization of five new subunits of TRAPP. Eur J Cell Biol 79(2):71-80
2) Sacher M, et al.  (1998) TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion. EMBO J 17(9):2494-503
3) Sacher M, et al.  (2001) TRAPP I implicated in the specificity of tethering in ER-to-Golgi transport. Mol Cell 7(2):433-42
4) Lynch-Day MA, et al.  (2010) Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy. Proc Natl Acad Sci U S A 107(17):7811-6