Standard Name	PCF11 1
Systematic Name	YDR228C
Feature Type	ORF, Verified
Description	mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping (1, 2, 3, 4, 5, 6)
Name Description	Protein 1 of Cleavage and polyadenylation Factor I 1

Chromosomal Location	ChrIV:923806 to 921926 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for PCF11
Molecular Function
Manually curated	mRNA binding (IDA, IMP) RNA polymerase II core binding (IDA, IMP, IPI)
Biological Process
Manually curated	mRNA cleavage (IDA) mRNA polyadenylation (IDA) termination of RNA polymerase II transcription (IDA, IMP)
Cellular Component
Manually curated	mRNA cleavage factor complex (IPI)

Classical genetics
conditional	total mRNA modification: abnormal
null	inviable
Large-scale survey
conditional	colony sectoring: increased
null	haploinsufficient inviable resistance to sodium arsenite: decreased
reduction of function	competitive fitness: increased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	152 total interaction(s) for 84 unique genes/features.
Physical Interactions	Affinity Capture-MS: 36 Affinity Capture-RNA: 3 Affinity Capture-Western: 19 Co-purification: 1 Protein-peptide: 3 Protein-RNA: 1 Reconstituted Complex: 8 Two-hybrid: 19
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 44 Positive Genetic: 6 Synthetic Growth Defect: 2 Synthetic Lethality: 7 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:923806 to 921926 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1881 923806..921926 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002636