GTB1/YDR221W Summary Help

Standard Name GTB1 1
Systematic Name YDR221W
Feature Type ORF, Verified
Description Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress (1, 2)
Name Description Glucosidase Two Beta-subunit 1
Chromosomal Location
ChrIV:907330 to 909438 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All GTB1 GO evidence and references
  View Computational GO annotations for GTB1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
53 total interaction(s) for 41 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 2
  • Co-fractionation: 1
  • Two-hybrid: 20

Genetic Interactions
  • Negative Genetic: 16
  • Phenotypic Enhancement: 6
  • Positive Genetic: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 702
Molecular Weight (Da) 79,907
Isoelectric Point (pI) 4.6
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:907330 to 909438 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2109 907330..909438 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002629
References cited on this page View Complete Literature Guide for GTB1
1) Wilkinson BM, et al.  (2006) Yeast GTB1 encodes a subunit of glucosidase II required for glycoprotein processing in the endoplasmic reticulum. J Biol Chem 281(10):6325-33
2) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76