Standard Name	TCP1 (see Nomenclature conflict Note)
Systematic Name	YDR212W
Alias	CCT1
Feature Type	ORF, Verified
Description	Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein (1, 2, 3, 4, 5)
Name Description	Tailless Complex Polypeptide

Chromosomal Location	ChrIV:887232 to 888911 | ORF Map | GBrowse
	Genetic position: 127 cM

	View Computational GO annotations for TCP1
Molecular Function
Manually curated	unfolded protein binding (IDA)
Biological Process
Manually curated	protein folding (IDA)
Cellular Component
Manually curated	chaperonin-containing T-complex (IDA, IPI)
High-throughput	plasma membrane (IDA)

Classical genetics
null	inviable
reduction of function	resistance to hygromycin: decreased resistance to cycloheximide: decreased
Large-scale survey
conditional	resistance to benomyl: decreased
null	competitive fitness: decreased filamentous growth: decreased haploinsufficient invasive growth: absent inviable resistance to sodium arsenite: decreased
overexpression	vegetative growth: decreased rate
reduction of function	competitive fitness: decreased resistance to benomyl: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	200 total interaction(s) for 167 unique genes/features.
Physical Interactions	Affinity Capture-MS: 46 Affinity Capture-Western: 2 Co-fractionation: 1 Co-purification: 1 Protein-peptide: 3 Reconstituted Complex: 1 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 9 Negative Genetic: 48 Positive Genetic: 6 Synthetic Growth Defect: 2 Synthetic Lethality: 77
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:887232 to 888911 | ORF Map | GBrowse
	Genetic position: 127 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1680 887232..888911 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002620