HST4/YDR191W Summary Help

HST4 BASIC INFORMATION

Standard Name HST4
Systematic Name YDR191W
Feature Type ORF, Verified
Description Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism (1, 2, 3)
Name Description Homolog of SIR Two (SIR2) 2, 4
GO Annotations All HST4 GO evidence and references
    View Computational GO annotations for HST4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Mutant Phenotype All HST4 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions HST4 All interactions details and references
38 total interaction(s) for 28 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 1
Genetic Interactions
  • Phenotypic Enhancement: 19
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 9
  • Synthetic Lethality: 3
  • Synthetic Rescue: 4
Sequence Information
ChrIV:842335 to 843447 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1113 842335..843447 2008-06-05 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002599

HST4 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for HST4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HST4]

1) Smith JS, et al.  (2000) A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. Proc Natl Acad Sci U S A 97(12):6658-63
2) Brachmann CB, et al.  (1995) The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev 9(23):2888-902
3) Starai VJ, et al.  (2003) Short-chain fatty acid activation by acyl-coenzyme A synthetases requires SIR2 protein function in Salmonella enterica and Saccharomyces cerevisiae. Genetics 163(2):545-55
4) Derbyshire MK, et al.  (1996) HST1, a new member of the SIR2 family of genes. Yeast 12(7):631-40