CDC1/YDR182W Summary Help

Standard Name CDC1 1
Systematic Name YDR182W
Alias DSC1 , DSR1 , ESP2
Feature Type ORF, Verified
Description Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution (2, 3, 4)
Name Description Cell Division Cycle 1
Chromosomal Location
ChrIV:827582 to 829057 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CDC1 GO evidence and references
  View Computational GO annotations for CDC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
conditional
null
Large-scale survey
conditional
null
overexpression
reduction of function
repressible
unspecified
Resources
71 total interaction(s) for 56 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 1

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 8
  • Negative Genetic: 23
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 3
  • Positive Genetic: 5
  • Synthetic Lethality: 3
  • Synthetic Rescue: 19

Resources
Expression Summary
histogram
Resources
Length (a.a.) 491
Molecular Weight (Da) 57,147
Isoelectric Point (pI) 10.28
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:827582 to 829057 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1476 827582..829057 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002590
References cited on this page View Complete Literature Guide for CDC1
1) Hartwell LH, et al.  (1970) Genetic control of the cell-division cycle in yeast. I. Detection of mutants. Proc Natl Acad Sci U S A 66(2):352-9
2) Paidhungat M and Garrett S  (1998) Cdc1 and the vacuole coordinately regulate Mn2+ homeostasis in the yeast Saccharomyces cerevisiae. Genetics 148(4):1787-98
3) Rossanese OW, et al.  (2001) A role for actin, Cdc1p, and Myo2p in the inheritance of late Golgi elements in Saccharomyces cerevisiae. J Cell Biol 153(1):47-62
4) Losev E, et al.  (2008) Cdc1p is an endoplasmic reticulum-localized putative lipid phosphatase that affects Golgi inheritance and actin polarization by activating Ca2+ signaling. Mol Cell Biol 28(10):3336-43