CSN9/YDR179C Summary

CSN9 BASIC INFORMATION

Standard Name	CSN9 1
Systematic Name	YDR179C
Feature Type	ORF, Verified
Description	Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling (1, 2)
Name Description	Cop9 SigNalosome subunit 1

GO Annotations	All CSN9 GO evidence and references
	View Computational GO annotations for CSN9
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	adaptation to pheromone during conjugation with cellular fusion (IGI, IMP) cullin deneddylation (IMP)
Cellular Component
Manually curated	signalosome (IDA)

Mutant Phenotype	All CSN9 Phenotype details and references
Classical genetics
null	mating efficiency: increased Cdc53p modification: increased recovery from pheromone-induced cell cycle arrest: decreased shmoo formation: increased rate
overexpression	recovery from pheromone-induced cell cycle arrest: increased
Large-scale survey
null	viable

Interactions	CSN9 All interactions details and references
	46 total interaction(s) for 21 unique genes/features.
Physical Interactions	Affinity Capture-MS: 20 Biochemical Activity: 1 Two-hybrid: 13
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 8 Phenotypic Suppression: 3

Sequence Information

ChrIV:819194 to 818706 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..489	819194..818706	2008-06-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002586

CSN9 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for CSN9

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CSN9]

1)	Maytal-Kivity V, et al. (2002) COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae. EMBO Rep 3(12):1215-21
2)	Wee S, et al. (2002) Conservation of the COP9/signalosome in budding yeast. BMC Genet 3():15

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