Standard Name	SDH4 1
Systematic Name	YDR178W
Alias	ACN18
Feature Type	ORF, Verified
Description	Membrane anchor subunit of succinate dehydrogenase; involved in coupling the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; SDH4 has a paralog, SHH4, that arose from the whole genome duplication (2, 3)
Name Description	Succinate DeHydrogenase 1

Chromosomal Location	ChrIV:817950 to 818495 | ORF Map | GBrowse

	View Computational GO annotations for SDH4
Molecular Function
Manually curated	contributes_to succinate dehydrogenase (ubiquinone) activity (IGI)
Biological Process
Manually curated	cellular respiration (IMP) mitochondrial electron transport, succinate to ubiquinone (TAS) tricarboxylic acid cycle (TAS)
Cellular Component
Manually curated	mitochondrial respiratory chain complex II (TAS)
High-throughput	mitochondrion (IDA)

Pathways	aerobic respiration, electron transport chain superpathway of TCA cycle and glyoxylate cycle TCA cycle, aerobic respiration

Classical genetics
null	acetic acid excretion: increased respiratory growth: decreased rate survival rate in stationary phase: decreased
unspecified	utilization of carbon source: absent
Large-scale survey
null	competitive fitness: decreased respiratory growth: decreased rate utilization of carbon source: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	48 total interaction(s) for 41 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 1 Affinity Capture-Western: 4 Co-localization: 1 PCA: 2 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 29 Phenotypic Suppression: 1 Positive Genetic: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:817950 to 818495 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..546 817950..818495 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002585