HMO1/YDR174W Summary

HMO1 BASIC INFORMATION

Standard Name	HMO1
Systematic Name	YDR174W
Alias	HSM2
Feature Type	ORF, Verified
Description	Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase (1, 2, 3, 4)
Name Description	High MObility group (HMG) family 1

GO Annotations	All HMO1 GO evidence and references
	View Computational GO annotations for HMO1
Molecular Function
Manually curated	DNA bending activity (IDA) rDNA binding (IDA) RNA polymerase I transcription factor activity (IDA) single-stranded DNA binding (IDA)
Biological Process
Manually curated	plasmid maintenance (IMP) regulation of transcription from RNA polymerase I promoter (IMP) regulation of transcription from RNA polymerase II promoter (IMP) transcription from RNA polymerase II promoter (IGI, IMP)
Cellular Component
Manually curated	cytoplasm (IDA) nuclear chromatin (ISS) nucleolar chromatin (IDA) nucleolus (IDA) nucleus (IDA)

Mutant Phenotype	All HMO1 Phenotype details and references
Classical genetics
null	oxidative stress resistance: decreased
Large-scale survey
null	bud morphology: abnormal budding pattern: abnormal competitive fitness: decreased fermentative growth: decreased rate freeze-thaw resistance: decreased lipid particle morphology: abnormal resistance to hygromycin B: decreased resistance to doxorubicin: decreased telomere length: increased toxin resistance: increased viable

Interactions	HMO1 All interactions details and references
	158 total interaction(s) for 136 unique genes/features.
Physical Interactions	Affinity Capture-MS: 79 Affinity Capture-RNA: 1 Affinity Capture-Western: 5 Co-purification: 1 Two-hybrid: 11
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 1 Phenotypic Enhancement: 4 Phenotypic Suppression: 1 Synthetic Growth Defect: 39 Synthetic Lethality: 12 Synthetic Rescue: 3

Sequence Information

ChrIV:812108 to 812848 | |

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..741	812108..812848	2008-06-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002581

HMO1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for HMO1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HMO1]

1)	Lu J, et al. (1996) Characterization of a high mobility group 1/2 homolog in yeast. J Biol Chem 271(52):33678-85
2)	Dolinski KJ and Heitman J (1999) Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase. Genetics 151(3):935-44
3)	Gadal O, et al. (2002) Hmo1, an HMG-box protein, belongs to the yeast ribosomal DNA transcription system. EMBO J 21(20):5498-507
4)	Merz K, et al. (2008) Actively transcribed rRNA genes in S. cerevisiae are organized in a specialized chromatin associated with the high-mobility group protein Hmo1 and are largely devoid of histone molecules. Genes Dev 22(9):1190-204

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