HMO1/YDR174W Summary Help

Standard Name HMO1 1
Systematic Name YDR174W
Alias HSM2
Feature Type ORF, Verified
Description Chromatin associated high mobility group (HMG) family member; involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase; relocalizes to the cytosol in response to hypoxia (1, 2, 3, 4, 5)
Name Description High MObility group (HMG) family 1
Chromosomal Location
ChrIV:812110 to 812850 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HMO1 GO evidence and references
  View Computational GO annotations for HMO1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 17 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
repressible
Resources
369 total interaction(s) for 284 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 94
  • Affinity Capture-RNA: 5
  • Affinity Capture-Western: 5
  • Biochemical Activity: 1
  • Co-purification: 1
  • PCA: 1
  • Two-hybrid: 11

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Negative Genetic: 166
  • Phenotypic Enhancement: 6
  • Phenotypic Suppression: 1
  • Positive Genetic: 14
  • Synthetic Growth Defect: 39
  • Synthetic Lethality: 16
  • Synthetic Rescue: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 246
Molecular Weight (Da) 27,544
Isoelectric Point (pI) 9.29
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:812110 to 812850 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..741 812110..812850 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002581
References cited on this page View Complete Literature Guide for HMO1
1) Lu J, et al.  (1996) Characterization of a high mobility group 1/2 homolog in yeast. J Biol Chem 271(52):33678-85
2) Dolinski KJ and Heitman J  (1999) Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase. Genetics 151(3):935-44
3) Gadal O, et al.  (2002) Hmo1, an HMG-box protein, belongs to the yeast ribosomal DNA transcription system. EMBO J 21(20):5498-507
4) Merz K, et al.  (2008) Actively transcribed rRNA genes in S. cerevisiae are organized in a specialized chromatin associated with the high-mobility group protein Hmo1 and are largely devoid of histone molecules. Genes Dev 22(9):1190-204
5) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30