SEC1/YDR164C Summary

SEC1 BASIC INFORMATION

Standard Name	SEC1 1, 2
Systematic Name	YDR164C
Feature Type	ORF, Verified
Description	Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function (3)
Name Description	SECretory 1

GO Annotations	All SEC1 GO evidence and references
	View Computational GO annotations for SEC1
Molecular Function
Manually curated	SNARE binding (IDA)
Biological Process
Manually curated	exocytosis (IMP, IPI) vesicle docking during exocytosis (IPI) vesicle fusion (IDA, IMP)
Cellular Component
Manually curated	cellular bud neck (IDA) cellular bud tip (IDA) plasma membrane (IDA)

Mutant Phenotype	All SEC1 Phenotype details and references
Classical genetics
conditional	endomembrane system morphology: abnormal heat sensitivity: increased invertase secretion: decreased invertase accumulation: increased
Large-scale survey
null	inviable

Interactions	SEC1 All interactions details and references
	124 total interaction(s) for 51 unique genes/features.
Physical Interactions	Affinity Capture-MS: 9 Affinity Capture-RNA: 1 Affinity Capture-Western: 22 Reconstituted Complex: 12 Two-hybrid: 4
Genetic Interactions	Dosage Growth Defect: 2 Dosage Lethality: 5 Dosage Rescue: 21 Phenotypic Suppression: 5 Synthetic Growth Defect: 1 Synthetic Lethality: 41 Synthetic Rescue: 1

Sequence Information

ChrIV:784213 to 782039 | |

Note: this feature is encoded on the Crick strand.

Genetic position: 94.77 cM

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2175	784213..782039	2008-06-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002571

SEC1 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for SEC1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SEC1]

1)	Novick P, et al. (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15
2)	Fields, C. and Schekman, R. (1985) Personal Communication, Mortimer Map Edition 9
3)	Carr CM, et al. (1999) Sec1p binds to SNARE complexes and concentrates at sites of secretion. J Cell Biol 146(2):333-44

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.