SSY1/YDR160W Summary Help

Standard Name SSY1 1
Systematic Name YDR160W
Alias SHR10 2 , RAA1 3
Feature Type ORF, Verified
Description Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; other members are Ssy1p, Ptr3p, and Ssy5p (4, 5)
Name Description Sulfonylurea Sensitive on YPD 1
Chromosomal Location
ChrIV:776163 to 778721 | ORF Map | GBrowse
Gbrowse
Genetic position: 92 cM
Gene Ontology Annotations All SSY1 GO evidence and references
  View Computational GO annotations for SSY1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
reduction of function
Resources
115 total interaction(s) for 99 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Co-purification: 1
  • Two-hybrid: 5

Genetic Interactions
  • Dosage Rescue: 4
  • Negative Genetic: 72
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 4
  • Positive Genetic: 6
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 4
  • Synthetic Rescue: 13

Resources
Expression Summary
histogram
Resources
Length (a.a.) 852
Molecular Weight (Da) 95,743
Isoelectric Point (pI) 9.39
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:776163 to 778721 | ORF Map | GBrowse
SGD ORF map
Genetic position: 92 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2559 776163..778721 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000002567
References cited on this page View Complete Literature Guide for SSY1
1) Jorgensen MU, et al.  (1998) Mutations in five loci affecting GAP1-independent uptake of neutral amino acids in yeast. Yeast 14(2):103-14
2) Klasson H, et al.  (1999) Ssy1p and Ptr3p are plasma membrane components of a yeast system that senses extracellular amino acids. Mol Cell Biol 19(8):5405-16
3) McCusker JH and Haber JE  (1990) Mutations in Saccharomyces cerevisiae which confer resistance to several amino acid analogs. Mol Cell Biol 10(6):2941-9
4) Forsberg H and Ljungdahl PO  (2001) Genetic and biochemical analysis of the yeast plasma membrane Ssy1p-Ptr3p-Ssy5p sensor of extracellular amino acids. Mol Cell Biol 21(3):814-26
5) Forsberg H, et al.  (2001) The role of the yeast plasma membrane SPS nutrient sensor in the metabolic response to extracellular amino acids. Mol Microbiol 42(1):215-28