Standard Name	CPR1 1 (see Nomenclature conflict Note)
Systematic Name	YDR155C
Alias	CYP1 , CPH1 2
Feature Type	ORF, Verified
Description	Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; protein abundance increases in response to DNA replication stress (2, 3, 4)
Name Description	Cyclosporin A-sensitive Proline Rotamase

Chromosomal Location	ChrIV:769000 to 768512 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for CPR1
Molecular Function
Manually curated	cyclosporin A binding (IMP) peptidyl-prolyl cis-trans isomerase activity (IDA)
Biological Process
Manually curated	ascospore formation (IMP) cellular protein metabolic process (IMP) histone deacetylation (IDA) positive regulation of meiosis (IGI, IMP)
Cellular Component
Manually curated	histone deacetylase complex (IPI) mitochondrial intermembrane space (IDA) nucleus (IDA) Set3 complex (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	IME1 mRNA accumulation: decreased freeze-thaw resistance: decreased heat sensitivity: increased histone H3 modification: increased resistance to sirolimus: increased resistance to cyclosporin A: increased sporulation: delayed vegetative growth: absent viable
Large-scale survey
null	competitive fitness: decreased resistance to mycophenolic acid: increased resistance to fenpropimorph: decreased resistance to tunicamycin: decreased resistance to cycloheximide: decreased resistance to streptomycin: decreased resistance to bleomycin: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	122 total interaction(s) for 82 unique genes/features.
Physical Interactions	Affinity Capture-MS: 65 Affinity Capture-RNA: 6 Affinity Capture-Western: 7 PCA: 4 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 3 Negative Genetic: 17 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 2 Synthetic Growth Defect: 5 Synthetic Lethality: 3 Synthetic Rescue: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:769000 to 768512 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..489 769000..768512 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002562