KGD2/YDR148C Summary Help

Standard Name KGD2 1
Systematic Name YDR148C
Feature Type ORF, Verified
Description Dihydrolipoyl transsuccinylase; component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated (1, 2)
Name Description alpha-KetoGlutarate Dehydrogenase 1
Chromosomal Location
ChrIV:755066 to 753675 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All KGD2 GO evidence and references
  View Computational GO annotations for KGD2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 6 genes
Resources
Pathways
Classical genetics
null
reduction of function
Large-scale survey
null
overexpression
unspecified
Resources
225 total interaction(s) for 170 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 30
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Protein-peptide: 1
  • Two-hybrid: 6

Genetic Interactions
  • Negative Genetic: 157
  • Phenotypic Suppression: 1
  • Positive Genetic: 26
  • Synthetic Growth Defect: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 463
Molecular Weight (Da) 50,430
Isoelectric Point (pI) 9.62
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:755066 to 753675 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1392 755066..753675 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002555
References cited on this page View Complete Literature Guide for KGD2
1) Repetto B and Tzagoloff A  (1990) Structure and regulation of KGD2, the structural gene for yeast dihydrolipoyl transsuccinylase. Mol Cell Biol 10(8):4221-32
2) Reinders J, et al.  (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6(11):1896-906