MKC7/YDR144C Summary Help

MKC7 BASIC INFORMATION

Standard Name MKC7 1
Systematic Name YDR144C
Alias YPS2 2
Feature Type ORF, Verified
Description GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p (1, 2)
Name Description Multicopy suppressor of Kex2 Cold sensitivity 1
GO Annotations All MKC7 GO evidence and references
    View Computational GO annotations for MKC7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All MKC7 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions MKC7 All interactions details and references
14 total interaction(s) for 8 unique genes/features.
Physical Interactions
  • Affinity Capture-Western: 1
Genetic Interactions
  • Dosage Rescue: 3
  • Phenotypic Enhancement: 3
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 6
Sequence Information
ChrIV:746099 to 744309 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1791 746099..744309 2008-06-05 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002551

MKC7 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Localization Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for MKC7

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MKC7]

1) Komano H and Fuller RS  (1995) Shared functions in vivo of a glycosyl-phosphatidylinositol-linked aspartyl protease, Mkc7, and the proprotein processing protease Kex2 in yeast. Proc Natl Acad Sci U S A 92(23):10752-6
2) Komano H, et al.  (1999) Purification and characterization of the yeast glycosylphosphatidylinositol-anchored, monobasic-specific aspartyl protease yapsin 2 (Mkc7p). J Biol Chem 274(34):24431-7