Standard Name	SAN1 1
Systematic Name	YDR143C
Feature Type	ORF, Verified
Description	Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition (2, 3, 4, 5)
Name Description	Sir Antagonist 1

Chromosomal Location	ChrIV:743874 to 742042 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SAN1
Molecular Function
Manually curated	ubiquitin-protein ligase activity (IDA)
Biological Process
Manually curated	nucleus-associated proteasomal ubiquitin-dependent protein catabolic process (IMP) protein ubiquitination involved in ubiquitin-dependent protein catabolic process (IDA, IMP) response to misfolded protein (IMP) response to stress (IMP)
Cellular Component
Manually curated	cytoplasm (IMP) nucleus (IDA)

Classical genetics
null	resistance to geldanamycin: decreased silencing: decreased
overexpression	silencing: decreased
Large-scale survey
null	competitive fitness: decreased haploinsufficient resistance to methyl methanesulfonate: decreased resistance to benzo[a]pyrene: decreased viable
overexpression	cell cycle progression: abnormal vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	119 total interaction(s) for 92 unique genes/features.
Physical Interactions	Affinity Capture-MS: 38 Affinity Capture-RNA: 2 Protein-RNA: 1 Two-hybrid: 28
Genetic Interactions	Dosage Lethality: 2 Dosage Rescue: 1 Negative Genetic: 14 Phenotypic Enhancement: 7 Phenotypic Suppression: 8 Positive Genetic: 6 Synthetic Growth Defect: 2 Synthetic Rescue: 10
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:743874 to 742042 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1833 743874..742042 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002550