Standard Name	DOP1 1
Systematic Name	YDR141C
Feature Type	ORF, Verified
Description	Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies (1, 2, 3, 4, 5)
Name Description	homolog of A. nidulans DOPey 1

Chromosomal Location	ChrIV:739997 to 734901 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for DOP1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	cell morphogenesis (IMP, ISS) endoplasmic reticulum organization (IMP) Golgi to endosome transport (IMP)
Cellular Component
Manually curated	endosome (IDA) trans-Golgi network (IDA)
High-throughput	cytoplasm (IDA) mitochondrion (IDA)

Classical genetics
conditional	endoplasmic reticulum morphology: abnormal heat sensitivity: increased GFP-Snc1p distribution: abnormal Sec71p-GFP distribution: abnormal GFP-Snc1p modification: decreased vacuolar morphology: abnormal
null	inviable
overexpression	budding pattern: abnormal cell size: increased cellular morphology: abnormal
Large-scale survey
null	inviable resistance to mefloquine: decreased
reduction of function	competitive fitness: decreased resistance to sirolimus: decreased resistance to hydroxyurea: decreased
repressible	chromosome/plasmid maintenance: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	103 total interaction(s) for 84 unique genes/features.
Physical Interactions	Affinity Capture-MS: 16 Affinity Capture-Western: 4 PCA: 9 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 4 Negative Genetic: 53 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 6 Synthetic Growth Defect: 3 Synthetic Lethality: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:739997 to 734901 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..5097 739997..734901 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002548