Standard Name	MTQ2 1
Systematic Name	YDR140W
Feature Type	ORF, Verified
Description	S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC (1, 2, 3, 4)
Name Description	Methyltransferase 1

Chromosomal Location	ChrIV:734138 to 734803 | ORF Map | GBrowse

	View Computational GO annotations for MTQ2
Molecular Function
Manually curated	contributes_to protein methyltransferase activity (IDA) protein methyltransferase activity (IDA) S-adenosylmethionine-dependent methyltransferase activity (IDA, IMP)
Biological Process
Manually curated	peptidyl-glutamine methylation (IDA) regulation of translation (IDA)
Cellular Component
Manually curated	eRF1 methyltransferase complex (IPI)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Classical genetics
null	tRNA-Lys and tRNA-Glu accumulation: increased cold sensitivity: increased resistance to hydroxyurea: decreased resistance to Calcofluor White: decreased resistance to polymixin B: decreased resistance to thiabendazole: decreased resistance to arsenic(3+): increased toxin resistance: increased vegetative growth: decreased
overexpression	ribosomal subunit accumulation: abnormal Bud23p accumulation: decreased toxin resistance: increased vegetative growth: decreased
Large-scale survey
null	budding index: decreased cell cycle progression in G1 phase: increased duration cell size: decreased glycogen accumulation: increased competitive fitness: decreased dessication resistance: decreased fermentative growth: decreased rate freeze-thaw resistance: decreased haploinsufficient heat sensitivity: increased resistance to acetic acid: decreased resistance to (S)-lactic acid: decreased resistance to oxalic acid: decreased resistance to sodium arsenite: increased resistance to hydrogen chloride: decreased resistance to benzo[a]pyrene: decreased resistance to doxorubicin: decreased stress resistance: increased toxin resistance: increased vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	vegetative growth: decreased rate vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	21 total interaction(s) for 16 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 2 Affinity Capture-Western: 1 Biochemical Activity: 1 Two-hybrid: 5
Genetic Interactions	Synthetic Growth Defect: 8 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:734138 to 734803 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..666 734138..734803 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002547