HPR1/YDR138W Summary Help

Standard Name HPR1
Systematic Name YDR138W
Alias TRF1 1
Feature Type ORF, Verified
Description Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p (2, 3, 4, 5, 6, 7, 8, 9)
Name Description HyPerRecombination 3
Chromosomal Location
ChrIV:730578 to 732836 | ORF Map | GBrowse
Gbrowse
Genetic position: 82 cM
Gene Ontology Annotations All HPR1 GO evidence and references
  View Computational GO annotations for HPR1
Molecular Function
Manually curated
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
Mutant phenotypes All HPR1 Phenotype evidence and references
Classical genetics
null
reduction of function
Large-scale survey
null
Resources
interactions All HPR1 Interaction evidence and references
256 total interaction(s) for 126 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 71
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 39
  • Biochemical Activity: 1
  • Co-crystal Structure: 1
  • Co-purification: 1
  • Reconstituted Complex: 6
  • Two-hybrid: 6
Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 10
  • Negative Genetic: 13
  • Phenotypic Enhancement: 10
  • Phenotypic Suppression: 11
  • Positive Genetic: 14
  • Synthetic Growth Defect: 20
  • Synthetic Lethality: 31
  • Synthetic Rescue: 20
Resources
Expression Summary
histogram
Resources
Protein Information All HPR1 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:730578 to 732836 | ORF Map | GBrowse
SGD ORF map
Genetic position: 82 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2259 730578..732836 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002545
References cited on this page View Complete Literature Guide for HPR1
1) Sadoff BU, et al.  (1995) Isolation of mutants of Saccharomyces cerevisiae requiring DNA topoisomerase I. Genetics 141(2):465-79
2) Chang M, et al.  (1999) A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signaling. Mol Cell Biol 19(2):1056-67
3) Aguilera A and Klein HL  (1990) HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene. Mol Cell Biol 10(4):1439-51
4) Chavez S, et al.  (2000) A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae. EMBO J 19(21):5824-34
5) Chavez S and Aguilera A  (1997) The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability. Genes Dev 11(24):3459-70
6) Chavez S, et al.  (2001) Hpr1 is preferentially required for transcription of either long or G+C-rich DNA sequences in Saccharomyces cerevisiae. Mol Cell Biol 21(20):7054-64
7) Merker RJ and Klein HL  (2002) hpr1Delta affects ribosomal DNA recombination and cell life span in Saccharomyces cerevisiae. Mol Cell Biol 22(2):421-9
8) Jimeno S, et al.  (2002) The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability. EMBO J 21(13):3526-35
9) Askree SH, et al.  (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63