SAC6/YDR129C Summary Help

SAC6 BASIC INFORMATION

Standard Name SAC6 1, 2
Systematic Name YDR129C
Alias ABP67 3
Feature Type ORF, Verified
Description Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton (4, 5, 6, 7)
Name Description Suppressor of ACtin 8
GO Annotations All SAC6 GO evidence and references
    View Computational GO annotations for SAC6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All SAC6 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions SAC6 All interactions details and references
118 total interaction(s) for 72 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 26
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Co-fractionation: 2
  • Co-localization: 1
  • Co-purification: 1
  • PCA: 4
  • Reconstituted Complex: 2
  • Two-hybrid: 1
Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 7
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 17
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 40
  • Synthetic Rescue: 11
Sequence Information
ChrIV:715377 to 713338 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 84 cM
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..21 715377..715357 2008-06-05 1996-07-31
Intron 22..132 715356..715246 2008-06-05 1996-07-31
CDS 133..2040 715245..713338 2008-06-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002536

SAC6 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SAC6

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SAC6]

1) Adams AE and Botstein D  (1989) Dominant suppressors of yeast actin mutations that are reciprocally suppressed. Genetics 121(4):675-83
2) Adams, A., et al.  (1989) Personal Communication, Mortimer Map Edition 10
3) Adams AE, et al.  (1989) A yeast actin-binding protein is encoded by SAC6, a gene found by suppression of an actin mutation. Science 243(4888):231-3
4) Karpova TS, et al.  (1995) Actin filaments in yeast are unstable in the absence of capping protein or fimbrin. J Cell Biol 131(6 Pt 1):1483-93
5) Adams AE, et al.  (1995) Isoform-specific complementation of the yeast sac6 null mutation by human fimbrin. Mol Cell Biol 15(1):69-75
6) Goodman A, et al.  (2003) The Saccharomyces cerevisiae calponin/transgelin homolog Scp1 functions with fimbrin to regulate stability and organization of the actin cytoskeleton. Mol Biol Cell 14(7):2617-29
7) Winder SJ, et al.  (2003) SCP1 encodes an actin-bundling protein in yeast. Biochem J 375(Pt 2):287-95
8) Novick P, et al.  (1989) Suppressors of yeast actin mutations. Genetics 121(4):659-74