DPB4/YDR121W Summary Help

DPB4 BASIC INFORMATION

Standard Name DPB4 1
Systematic Name YDR121W
Feature Type ORF, Verified
Description Shared subunit of DNA polymerase (II) epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencing (1, 2, 3, 4)
Name Description DNA Polymerase B (II) subunit
GO Annotations All DPB4 GO evidence and references
    View Computational GO annotations for DPB4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All DPB4 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions DPB4 All interactions details and references
91 total interaction(s) for 39 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 34
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 11
  • Co-fractionation: 1
  • Co-purification: 4
  • Reconstituted Complex: 4
  • Two-hybrid: 5
Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 12
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 10
  • Synthetic Lethality: 4
  • Synthetic Rescue: 3
Sequence Information
ChrIV:693583 to 694173 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..591 693583..694173 2008-06-05 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002528

DPB4 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for DPB4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for DPB4]

1) Ohya T, et al.  (2000) Structure and function of the fourth subunit (Dpb4p) of DNA polymerase epsilon in Saccharomyces cerevisiae. Nucleic Acids Res 28(20):3846-52
2) Dua R, et al.  (2000) Subunit interactions within the Saccharomyces cerevisiae DNA polymerase epsilon (pol epsilon ) complex. Demonstration of a dimeric pol epsilon. J Biol Chem 275(37):28816-25
3) Li Y, et al.  (2000) Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. J Biol Chem 275(30):23247-52
4) Iida T and Araki H  (2004) Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiae. Mol Cell Biol 24(1):217-27