ALT2/YDR111C Summary Help

Standard Name ALT2 1, 2
Systematic Name YDR111C
Feature Type ORF, Uncharacterized
Description Catalytically inactive alanine transaminase; expression is repressed in the presence of alanine and repression is mediated by Nrg1p; ALT2 has a paralog, ALT1, that arose from the whole genome duplication (2, 3, 4)
Name Description ALanine Transaminase 2
Chromosomal Location
ChrIV:679764 to 678241 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ALT2 GO evidence and references
  View Computational GO annotations for ALT2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 4 genes
Resources
Large-scale survey
null
overexpression
Resources
35 total interaction(s) for 30 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 17
  • Positive Genetic: 3
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 507
Molecular Weight (Da) 56,769
Isoelectric Point (pI) 5.61
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:679764 to 678241 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1524 679764..678241 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002518
References cited on this page View Complete Literature Guide for ALT2
1) Anaya V, et al.  (2003) personal communication
2) Blank LM, et al.  (2005) Metabolic-flux and network analysis in fourteen hemiascomycetous yeasts. FEMS Yeast Res 5(6-7):545-58
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Penalosa-Ruiz G, et al.  (2012) Paralogous ALT1 and ALT2 Retention and Diversification Have Generated Catalytically Active and Inactive Aminotransferases in Saccharomyces cerevisiae. PLoS One 7(9):e45702